| Objective: Recently, there is a globally increasing trend of type2diabetes mellitus, and the numerous complications have made type2diabetesmellitus the fifth ranked disease with high mortality in the world. The mainpathogenesis of type2diabetes mellitus is insulin resistance and impairmentin β cell. Recent findings show that gamma-glutamyltransferase (GGT) isclosely related to type2diabetes mellitus pathogenesis and its complications.By means of analyzing serum GGT changes and carotid atheroscleroticplaques formation in type2diabetes mellitus group and control group,discussing whether there is correlation between elevated GGT and bloodglucose in type2diabetes mellitus patients, and whether there is correlationbetween GGT and carotid atherosclerosis. That can provide new evidence forthe early discovery, prevention and treatment of type2diabetes mellitus.Methods:35type2diabetic patients hospitalized in EndocrinologyDepartment of the Second Hospital of HeBei Medical University from2011February to2012February were collected. All patients that conformed to thediagnosis and classification standards of diabetes made by WHO in1999hadbeen taken carotid ultrasound or carotid angiography. Meanwhile, all patientswere excluded liver disease and gallbladder disease. In the same period,40cases excluding diabetes, hepatobiliary disease, hypertension and otherdiseases were taken as the control group.(1) The general clinical data of eachpatient including gender, age, duration of type2diabetes, alcohol drinking,past medical history, family history, weight, height and blood pressure werecollected, and body mass index(BMI) was also calculated.(2) Fasting serumwas taken to measure fasting plasma glucose (FPG), triglyceride (TG), totalcholesterol (TC), high density lipoprotein cholesterol (HDL-C), low densitylipoprotein cholesterol (LDL-C) and GGT.(3) Abdominal ultrasonography and carotid ultrasonography were measured by one doctor specialized inultrasound using the same color Doppler ultrasonography device. SPSS17.0was adopted to do the statistical analysis. Measurement data were expressed asmean number±standard deviation (x±s). The data followed normaldistribution were compared by t test, while the data didn't follow normaldistribution were analyzed by Mann-Whitney rank sum test. Count data werecompared by chi-square test, and classification variables were expressed aspercentages (%). Multivariate analyses were performed using logisticregression to identify predictors of carotid atherosclerotic plaque formation. P＜0.05meant that there was statistical significance.Result:1In the75cases,35cases of type2diabetes mellitus were observe group.The mean age of diabetic patients was50.51±13.20years old, including21males and14females; The control group had40healthy cases and thecorresponding mean age was47.40±10.64years old, including17males and23females. There were no statistically significant differences between theages and genders of the two groups (P>0.05). In the observe group of type2diabetes mellitus, the mean SBP, mean DBP and BMI was131.97±20.38mmHg,77.94±15.42mmHg and25.47±3.55kg/m2respectively. In the controlgroup, the mean SBP, mean DBP and BMI was126.28±18.73mmHg,76.40±9.49mmHg and24.46±2.77kg/m2respectively. There was nostatistical significance in SBP, DBP and BMI of the two groups (P>0.05).2FBG, TG, HDL-C, GGT in the observe group of type2diabeticpatients were higher than those in the control group (P<0.05); TC and LDL-Cwere higher in the observe group of type2diabetic patients, but there were nostatistically significant differences between the two groups (P>0.05).315cases (42.86%) have carotid atherosclerosis in the observe group oftype2diabetes mellitus, including9cases (25.71%) with bilateral carotidplaques. On the other hand, there were only2cases with carotidatherosclerosis (5%) in the control group, including1case (2.5%) withbilateral carotid plaques. 4Logistic regression analysis showed that age (OR:2.378,95%CI:1.216~4.649, P=0.011), hyperglycosemia (OR:0.167,95%CI:0.039~0.709,P=0.015) and serum GGT (OR:3.319,95%CI:1.258~8.753, P=0.015) werethe independent predictors of carotid plaques.Conclusion: Serum GGT in patients with type2diabetes mellitus werehigher than the healthy people, and the elevated serum GGT was closelyrelated to the formation of carotid plaques. GGT was the independentpredictor of carotid atherosclerosis. |
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