| Objective: To investigate the relationship between ABO blood group and the disease of processus vaginalis dysplasia in children,and to analyze the influence of ABO blood group on the disease of processus vaginalis dysplasia,this study provides a new idea for the treatment and prevention of the disease of processus vaginalis dysplasia in children.Methods: In this study,according to the inclusion and exclusion criteria,Medical records of children in the Department of Surgery,the First Affiliated Hospital of Shihezi University from January 2003 to December2021 were collected.Children were divided into control group and case group according to whether they had PV-related diseases.The case group was further divided into various subgroups.General information and ABO blood group information of all enrolled children were collected.Calculate the distribution characteristics of ABO blood group in children,analyze the influencing factors of PV related diseases in children,and the differences in the constituent ratios of PV related diseases among different ABO blood group antigens.Calculate the relative risk(OR value)of each ABO blood group antigen for PV related diseases.Logistic regression analysis was used to analyze the correlation between ABO blood group and the disease of processus vaginalis dysplasia after adjusting for multiple factors,and stratified analysis was performed in different genders,different ethnic groups and different age groups.Results: A total of 5336 pediatric medical records were collected in this study,the ABO blood group distribution was B > A > O > AB.There was statistical significance in ABO blood group composition ratio between case group and control group(P < 0.05).The IIH composition ratio of children in different age groups,different genders,different nationalities and ABO blood groups was different(P < 0.05).There was A significant difference in the constituent ratio of IIH between type A and type AB compared with type O in children(P < 0.0083).The OR value of H antigen blood groups relative to non-H antigen blood group was 1.384(95%CI: 1.162-1.649),and the OR value of A and B antigen blood groups cooccurring relative to single antigen blood group was 0.763(95%CI: 0.613-0.950).Univariate and multivariate Logistic analysis showed that there were significant differences in the risk of IIH among children with different ABO blood groups.Age stratification showed that the risk of IIH in infants with AB blood group was 0.488times(95%CI: 0.328-0.725)higher than that in children with O blood group.The risk of IIH in preschool children with type A was 0.607 times(95%CI: 0.390-0.945)that of type O.There was no significantdifference in the risk of IIH in school-age children with different ABO blood types.Gender stratification showed that when children were less than or equal to 6 years old,compared with blood type O,there was A statistically significant difference in IIH risk between boys AB and girls A and AB.Ethnic stratification showed that,when children were less than or equal to 6 years of age,there was a statistically significant difference in the risk of developing IIH among Han children with non-O blood type,while there was no statistically significant difference between ABO blood type and IIH risk among ethnic minority children.Conclusion:1.ABO blood group is associated with indirect inguinal hernia in children with patent processus vaginalis,and blood group antigen H may affect the physiological atresia of processus vaginalis2.In the group of children aged 6 years and under treated in the hospital,the risk of indirect inguinal hernia in infants and children with AB blood type and preschool children with A blood type is lower than that in children with O blood type in the same age group. |
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