Expression And Clinical Significance Of Gal-3 In Plasma Of Patients With Chronic Heart Failure And Type 2 Diabetes Mellitus

Objective:This article aims to investigate the expression and clinical significance of galectin-3（Gal-3）in plasma of patients with chronic heart failure and type 2 diabetes.Methods:120 patients treated from March 2022 to the Department of Cardiology and Geriatrics of the First Affiliated Hospital of Dali University in November 2022,80patients with chronic heart failure with type 2 diabetes,and 40 patients without heart failure with type 2 diabetes,and 40 healthy control groups were collected.The basic clinical characteristics between groups,including general data of Gal-3,HbA1c,BNP,LVEF,UA and GFR.The group with chronic heart failure and type 2 diabetes mellitus was divided by cardiac function grade（grade II,III,IV）and ejection fraction（HFp EF,HFmr EF,HFr EF）,and relevant data were compared between the groups.To analyze the expression of Gal-3 alone and in combination with BNP and HbA1c in patients with chronic heart failure combined with type 2 diabetes.Results:1.Plasma Gal-3 levels were significantly in Creased in the chronic heart failure group with type 2 diabetes mellitus（12.85（9.93,14.71））,The difference between groups was statistically significant.2.Gal-3 and BNP（r_s=0.817,P<0.001）,Gal-3 and HbA1c（r_s=0.631,P<0.001）,BNP and HbA1c（r_s=0.451,P<0.001）,all positively correlated;Gal-3 was negatively correlated with LVEF（r_s=-0.541,P<0.001）,The difference was statistically significant.3.Compared with the type 2 diabetes group with chronic heart failure and type 2diabetes,there were statistically significant differences between UA,Crea,Urea,GFR,and HDL-C（P<0.001）.UA was higher in the chronic heart failure group than HFp EF and HFmr EF in the HFr EF group.The GFR of chronic heart failure and type 2diabetes mellitus group was lower than that of type 2 diabetes group and healthy group,and the heart function grade IV group was lower than that of grade II and III.HDL-C was lower than that in the healthy group,and the difference was statistically significant（P<0.05）.4.Plasma Gal-3 level predicted area AUC=0.936,sensitivity 90%,specificity82.5%in the diagnosis of chronic heart failure complicated with type 2 diabetes mellitus,statistically significant（P<0.001）.5.The area,sensitivity and specificity of Gal-3+BNP and Gal-3+HbA1c co mbined with chronic heart failure combined with type 2 diabetes mellitus predi cted the area,sensitivity and specificity under the ROC curve,respectively:AU C _Gal-3+BNP=0.956,90%,85%;AUC_Gal-3+HbA1c=0.813,76.3%,85%;statistically significant（P<0.001）.6.When Gal-3,BNP and HbA1c were combined,the diagnosis of chronic heart failure combined with type 2 diabetes mellitus predicted the area AUC=0.999 under the ROC curve was 0.970,and the sensitivity 91.3%specificity 90%,statistically significant（P<0.001）.Conclusion:1.Plasma Gal-3 levels are higher in chronic heart failure with type 2 diabetes compared with type 2 diabetes in patients without heart failure.2.Plasma Gal-3 level showed a strong positive correlation with serum BNP and HbA1c levels,and had a negative correlation with LVEF,and the control of blood glucose level had a certain effect on the severity of the disease.3.The combination of plasma Gal-3,serum BNP and HbA1c in the diagnosis and prediction of diabetic HF patients has higher sensitivity and specificity than single indicators and two combination of indicators,which provides a diagnosis and treatment idea for the early clinical diagnosis of diabetic heart failure.