Application Value Of Glycosylated Hemoglobin In Type 2 Diabetes Mellitus With Subclinical Hypothyroidism

Objective: To analyze the correlation between glycosylated hemoglobin(HbA1c)and blood glucose in type 2 diabetes mellitus patients with subclinical hypothyroidism,and to evaluate the application value of HbA1 c in type 2 diabetes mellitus patients with subclinical hypothyroidism.Methods: A total of 168 patients with type 2 diabetes mellitus were divided into normal thyroid function group and subclinical hypothyroidism group according to the level of thyroid stimulating hormone(TSH).Gender,age,course of disease,BMI,fasting blood glucose,120 minutes postprandial blood glucose,hemoglobin and thyroid hormone,thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TgAb)were compared between the two groups.and the correlation between HbA1 c and fasting blood glucose and 120 minutes postprandial blood glucose were analyzed.Results:1.The proportion of women,TPOAb and TgAb in type 2 diabetes mellitus patients with subclinical hypothyroidism were significantly higher than those in normal thyroid function group,while HbA1 c,hemoglobin,FT4 and BMI were significantly lower than those in the normal group.There was no significant difference in age,course of disease,fasting blood glucose,120 minutes postprandial blood glucose and FT3 between the two groups.2.Pearson correlation analysis showed that HbA1 c was correlated with fasting blood glucose and 120 minutes postprandial blood glucose in type 2 diabetic patients with normal thyroid function,and the correlation coefficients were 0.390 and 0.285,respectively.HbA1 c in type 2 diabetes mellitus patients with subclinical hypothyroidism was correlated with fasting blood glucose with a correlation coefficient of 0.231,but not with 120 minutes postprandial blood glucose.Conclusions: Glucose metabolism in patients with type 2 diabetes mellitus complicated with subclinical hypothyroidism should not be evaluated only by glycosylated hemoglobin.