Analysis Of Clinical Characteristics And Risk Factor Of Ulcerative Colitis With Amebic

Objective: To study the clinical and endoscopic characteristics of ulcerative colitis with and without amoeba infection,improve the understanding of intestinal lesions and explore the risk factors of ulcerative colitis with and without amoeba infection.Methods: A total of 109 patients diagnosed with UC and screened for amoeba infection by fecal microscopy were selected from the Affiliated Hospital of Inner Mongolia Medical University from January 2013 to December 2022.According to whether the patients with UC combined with and without amoeba infection,they were divided into UC combined with and without amoeba infection group,namely case group and control group.The clinical characteristics of the two groups were compared and the risk factors of UC patients with amoeba infection were analyzed.Result: A total of 109 subjects were included in this study,including 37 in the case group and72 in the control group.1.There were no significant differences in age,gender,course of disease and clinical type between the case group and the control group.2.The disease degree and lesion range of UC patients in the two groups were compared,have a significant difference(P<0.05).The severity of the disease in the case group was more severe than that in the control group.In addition,the severity of the disease in the case group was mostly severe,and the lesions were mainly E3(extensive colonoscopy: inflammation involving the splenic flexure mostly occurred near or even the whole colon under endoscopy).3.Both patients in the case group and the control group showed congestion erosion,irregular/superficial ulcers,and granuloid sensation under endoscopy,and there was no statistical significance in comparison of endoscopic performance between the two groups.4.Laboratory indicators(serum albumin,white blood cell count,erythrocyte sedimentation rate,hemoglobin and C-reactive protein)were compared between the two groups,and there were statistically significant differences in serum albumin,hemoglobin and C-reactive protein(P<0.05).5.The previous drug use history of the two groups was compared,and the previous drug use history of hormones,Infliximab(IFX)and azathioprine was statistically significant(P<0.05).There was no significant difference in the drug history of cyclosporine and thalidomide between the two groups.6.Multivariate Logistic regression analysis showed that elevated CRP(OR=6.302;95%CI: 1.325 ～ 29.979;P < 0.05),past hormone use(OR= 5.220;95%CI: 1.244 ～21.901;P < 0.05)and infliximab(IFX)(OR= 5.781;95%CI: 1.147 ～ 29.134;P < 0.05)were independent risk factors for UC combined with ameba infection.Conclusion:1.Patients with severe UC disease were more likely to be complicated with amoeba infection,and the severity of the disease accounted for more than severe,and the lesions were mainly E3(extensive colonoscopy).2.Serological examination of UC patients with amoeba infection was prone to decrease of albumin and hemoglobin,and increase of C-reactive protein high.3.Prior use of hormones and infliximab(IFX)increases the risk of ameba infection in UC patients.