Clinical Observation On The Treatment Of RSA-PTS By Bushen Huoxue Recipe

Objective: Through a clinical randomized controlled study,we observed the coagulation index,ultrasound uterine artery resistance,clinical symptoms and the development of embryos at twelve weeks in the three groups before and after treatment to assess the effectiveness of kidney tonification and blood activation methods in the treatment of recurrent miscarriage and easy embolism as well as their advantages,and to provide a theoretical basis for seeking a safe and effective treatment plan for clinical treatment.Methods: In the first place,PASS2020 software was applied to calculate the total sample size of one hundred and forty-six cases.In the research,there were one hundred and forty-six patients with recurrent miscarriage combined with easy embolism who came to our outpatient clinic or were hospitalized from October 2021 to November 2022 were selected for the study.All patients were aware of the study and had informed consent forms.Then,random grouping was used to divide them into three groups.Observation group one is the pure Chinese medicine group,using the Bushen Huoxue Recipe(Cuscuta sinensis fifteen grams,Sequoia sinensis ten grams,Parasitic loranthus fifteen grams,Agaricus blazei six grams,Du Zhong ten grams,Atractylodes macrocephala ten grams,Radix Codonopsis pilosulae fifteen grams,Angelica sinensis ten grams,Tian Qi three grams,Salvia miltiorrhiza ten grams);the matched group was treated with anticoagulantLMWH injection(Produced in Hebei Changshan;zero point four millilitre;four thousand one hundred internationalunit).At the same time,the remaining group was treated with a combination of Chinese and Western medicine.Chinese medicine symptom score,PT series,serum homocysteine(Hcy)and ultrasound uterine artery resistance(RI)were performed before treatment.The treatment was repeated until about twelve weeks of pregnancy to check the status of all indicators(ultrasonography,PT series,etc.),and combine the statistical results to determine the efficacy.In the course of treatment,the adverse drug reactions and their vital signs,routine blood test,biochemical series,electrocardiogram and so on of all patients were monitored at all times.Results:1.General data: A total of one hundred and twenty-five cases were collected,of which there were forty-three cases in observation group one,forty-four cases in the second group and thirty-eight cases in the remaining group.There was no statistical difference in age distribution,number of miscarriages,time of miscarriage,coagulation index,homocysteine,resistance index and pre-treatment Chinese medicine symptom score among the three groups(P > 0.05),which were comparable.2.Observation indicators(tests,examinations): D-Dimer,resistance index,fibrinogen and homocysteine falled,other indicators have heightened;Among them,the levels of D-Dimer and resistance index in the second group were more below than simple herbal group and western medicine alone group in order after treatment,there was a statistically significant difference(P < 0.001);Prothrombin time after treatment also showed statistical difference(P < 0.05).Nevertheless,there is no difference in other indicators among the three groups.(P > 0.05).3.Chinese medicine symptom score: All the patients enrolled had improved symptoms,so the scores were lower than before.Furthermore,the scores in Chinese medicine and western medicine group two were more below than simple herbal group and western medicine alone group in order after treatment,with significant statistical differences(P < 0.001).4.Curative effect: Excluding twelve-week abortion,embryo abortion and aggravated symptoms,the effective rates of the three groups were respectively 74.4% 、 90.9% and 52.6% respectively,with statistically significant differences(P < 0.001).5.Embryonic development at twelve weeks: thirty-two people in experimental group one,up to forty people in experimental group two and only twenty people in the remaining group,which not only the symptoms were relieved,but also the embryos developed normally at 12 weeks,with statistically significant differences(P < 0.001).6.Adverse drug reaction: A total of four patients developed abnormal liver function during the treatment,while the remaining patients’ ECG,liver and kidney function,and blood routine during the treatment were within the normal reference range,so the treatment regimens in all three groups had some safety.In addition,patients who developed abnormal liver function discontinued heparin for liver protection and withdrew from the study;In addition,six cases were from observation group 2 and control group respectively discontinued heparin on their own after developing subcutaneous hard nodules and withdrew from the study.The final one hundred and twenty-five patients experienced no significant adverse effects after treatment.Conclusion: Bushen Huoxue Recipe has a good effect in treating recurrent abortion complicated with thrombophilia.The combination of Bushen Huoxue Recipe and anticoagulant group is better than the traditional Chinese drug group and the western drug group in turn,which in relieving the clinical symptoms,lowering the D-Dimer level,resistance index value and improving the PTS of patients.The final clinical total effective rate(twelve-week abortion success rate)was 90.9% in the integrated traditional Chinese and western group,74.4% in the simple herbal group and 52.6% in the simple western medicine group,and there was a very obvious healing effect.Therefore,the Bushen Huoxue Recipe is safe and effective in treating this disease without obvious side effects,and is suitable for clinical promotion.