| Objective:To observe the clinical efficacy and safety of the external application of Jiawei Jinhuang Paste combined with colchicine tablets in the treatment of acute gouty arthritis with damp-heat accumulation syndrome,give full play to the role of external treatment of traditional Chinese medicine,and combine traditional Chinese and western medicine to provide a train of thought for clinical treatment of this disease,so that patients with acute gouty arthritis have a good treatment choice,and patients with acute gouty arthritis have greater benefits.Methods:Select 80 patients with acute gouty arthritis with damp-heat accumulation syndrome that meet the inclusion criteria,and randomly divide them into control group and observation group,with 40 patients in each group.All patients received health education on gout,including daily diet precautions.The control group was treated with oral colchicine tablets,while the observation group was treated with the external application of Jiawei Jinhuang Paste combined with colchicine tablets.One week was a course of treatment.After one week of continuous treatment,the scores of joint pain,joint tenderness,joint redness and swelling,joint dysfunction and visual analogue score(VAS)of the two groups of patients before and after treatment were recorded,the levels of serum uric acid(SUA)and C-reactive protein(CRP)of the two groups of patients before and after treatment were measured,the adverse reactions during treatment were recorded,and the safety was evaluated.The efficacy was evaluated according to the efficacy evaluation criteria,and finally analyzed using statistical methods.Results:1.After treatment,the total effective rate of the observation group was 90.63%,and that of the control group was 78.13%.Compared with the control group,the overall treatment effect of the observation group was better,with a significant difference(P<0.05).2.After treatment,the joint pain score of patients in the observation group decreased compared with that before treatment,with a significant difference(P<0.05).The joint pain score of patients in the control group was significantly lower than that before treatment(P<0.05).After treatment,there was a significant difference in joint pain scores between the two groups(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P <0.05).3.After treatment,the joint tenderness score of patients in the observation group decreased compared with that before treatment,with a significant difference(P<0.05).The joint tenderness score of patients in the control group was significantly lower than that before treatment(P<0.05).After treatment,there was a significant difference in the score of joint tenderness between the two groups(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P <0.05).4.After treatment,the joint swelling score of patients in the observation group decreased compared with that before treatment,with a significant difference(P<0.05).The joint swelling score of patients in the control group decreased compared with that before treatment,with a significant difference(P<0.05).After treatment,there was a significant difference in the score of joint redness between the two groups(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P<0.05).5.After treatment,The score of joint dysfunction in the observation group was lower than that before treatment,The difference was significant compared with that before treatment(P<0.05).The score of joint dysfunction in the control group was significantly lower than that before treatment(P<0.05).After treatment,there was a significant difference in the score of joint dysfunction between the two groups(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P<0.05).6.After treatment,the VAS score of patients in the observation group decreased compared with that before treatment,with a significant difference(P<0.05).The VAS score of patients in the control group was significantly lower than that before treatment(P<0.05).After treatment,the VAS scores of the two groups were significantly different(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P<0.05).7.There was no significant difference in SUA level between the two groups before treatment(P>0.05);After treatment,the SUA of patients in both groups decreased.Compared with that before treatment,there was no significant difference in the control group(P>0.05),but there was significant difference in the observation group(P<0.05).8.After treatment,the CRP of the observation group was lower than that before treatment,and the difference was significant(P<0.05).The CRP level of patients in the control group decreased compared with that before treatment,with a significant difference(P<0.05).After treatment,there was a significant difference in CRP levels between the two groups(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P<0.05).9.After treatment,the ESR of the observation group was lower than that before treatment,and the difference was significant(P<0.05).The ESR level of patients in the control group decreased compared with that before treatment,with a significant difference(P<0.05).After treatment,there was a significant difference in ESR levels between the two groups(P<0.05).The difference between the two groups before and after treatment was significantly greater in the observation group than in the control group(P<0.05).10.During the treatment,7 adverse reactions occurred in the observation group,with the incidence of 21.87%,and 5 adverse reactions occurred in the control group,with the incidence of 15.62%.The adverse reactions in both groups were mild,and no patients fell off.Compared with the control group,there was no significant difference in the incidence of adverse reactions(P <0.05).Conclusion:1.Compared with simple use of colchicine tablets,Jiawei Jinhuang paste combined with colchicine tablets has better overall efficacy in treating patients with acute gouty arthritis with damp-heat accumulation syndrome,This is a good method for clinical treatment of acute gouty arthritis.2.External application of Jiawei Jinhuang paste can improve the clinical symptoms and signs of patients to a certain extent,such as joint pain,joint tenderness,joint swelling and joint dysfunction.3.External application of Jiawei Jinhuang paste can reduce the VAS pain level of patients to a certain extent.4.External application of Jiawei Jinhuang paste can reduce the level of CRP,ESR and SUA in patients to a certain extent.5.External application of Jiawei Jinhuang paste combined with colchicine tablets has low adverse reaction rate and good safety in treating patients with acute gouty arthritis with damp-heat accumulation syndrome. |
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