| Research objectives:Through data mining of the literature on the treatment of acute tracheal bronchitis by traditional Chinese medicine,the syndrome types and prescriptions mentioned in the literature were analyzed,so as to excavate the syndrome rules and prescription selection rules of acute tracheal bronchitis,and to sort out and discuss the TCM discrimination and treatment rules of acute tracheal bronchitis,which provide certain reference for clinical medication and scientific research.Research methods:Literature on the treatment of acute tracheobronchitis by TCM published by various physicians in the past 40 years was retrieved from CNKI,Wanfang Database,Weipu Chinese Journal and China Biomedical Literature Database.According to the inclusion and exclusion criteria,the literature with relatively complete information on diagnosis and syndrome differentiation was selected.Established a literature database,conducted data standardization processing on the selected literature,Excel,IBM SPSS Modeler 18.0,IBM SPSS Statistics 25.0 and Cytoscape3.8.0 data mining software were used to analyze the frequency,association rules and clustering of data information,and performed visualization processing.Results:A total of 274 literatures were screened out in this study,among which268 syndrome types were explicitly mentioned,including 285 prescriptions,involving 204 TCM,and the total frequency of TCM use was 2953 times.(1)In terms of syndrome elements,lung and surface were the main syndrome-location elements of acute tracheobronchitis,and also involved spleen,stomach and liver.The main syndromic elements were heat and external wind,and also involved phlegm,cold,dampness,dryness,qi deficiency,Yin deficiency,etc.There were 12 types of syndrome element combinations,among which four syndrome element combinations appeared most frequently.The combination of pathogenic syndromes and elements mainly consists of exogenous wind and heat,phlegm and heat,exogenous wind and cold.The combination of syndrome elements of disease location was dominated by the combination of syndrome elements of two-disease location and syndrome elements of single disease location.The combination of syndrome elements of two-disease location was dominated by lung and surface,and the syndrome elements of single disease location was dominated by lung.(2)According to the usage of TCM prescriptions,we can see that the most commonly used prescriptions are Zhisou powder and Maxingshigan decoction,followed by Mahuang decoction,Sangju Yin,Yinqiao powder,Erchen decoction,Qingjin phlegm decoction,Sanziyangqin decoction,Qianjinweijin decoction,etc.(3)According to the situation of medicine use,the main medicines used were phlegm-relieving cough and asthmatic-relieving medicines,heat-clearing medicines,skin-relieving medicines,deficiency toning medicines,qi regulating medicines,etc.The high-frequency Chinese medicines used with frequency ≥ 15% included licorice,almond,platycodon,ephedra,scutellaria scutellaria,tangerine peel,aster,mulberry bark,Baibuu,forehu and Houttuynia cordata.In terms of medicine flavor and meridian tropism,medicinal property are combined with cold and warm,and cold,warm and flat dominate;The medicinal taste is dominated by bitter,occitrin and sweet,and meridian distribution mainly focuses on lung,spleen,stomach,heart and large intestine.(4)According to the analysis of medicine association rules,the highest degree of elevation and the greatest correlation among the duplex medication was Aster tataricus-flos farfarae,followed by ephedra-gypsum;Among the triple medication,the highest degree of improvement and the highest correlation were Cynanchum glaucescens-Herba Schizonepetae-the tuber of stemona,followed by honeysuckle-forsythia-almond;Among the quadruple medication,Cynanchum glaucescens-Herba Schizonepetae-the tuber of stemona-Platycodon grandiflorum had the highest degree of improvement and the greatest correlation,and it could be found that the quadruple medication were mainly composed of addition or subtraction on the basis of Zhisou powder,Maxingshigan decoction and Jiegengxingren prescription.(5)According to medicine cluster analysis,the top 30 high-frequency medicines except licorice could be grouped into 5 categories.Conclusion:(1)Syndrome: Acute tracheobronchitis is widely distributed,mainly lung and surface.The disease generally belongs to the combination of excess and deficiency syndrome,and mainly to excessive pathogen.Clinically,disease and disease position affect each other,closely related,must be carefully identified in clinical differentiation and treatment.(2)Prescription: The efficacy of the prescription is mainly to promote lung dispelling pathogenic qi,clearing heat and eliminating phlegm and relieving cough.Zhisou Powder and Maxingshigan decoction are mostly used.(3)Medicine flavor and meridian tropism: The medicinal property are mainly cold,warm and flat,the cold and warm combined;The medicinal taste is dominated by bitter,occitrin and sweet,and meridian distribution mainly focuses on lung,spleen and stomach.(4)Medicine efficacy: Drug efficacy tends to phlegm and cough,heat and fire clearing and detoxification,wind dissipation and surface relief,etc.(5)Medicine association and clustering: According to the association rules,it is important to use the drug combinations in treatment,which include Aster tataricus-flos farfarae,ephedra-gypsum,honeysuckle-forsythia-almond,Cynanchum glaucescens-Herba Schizonepetae-the tuber of stemona-Platycodon grandiflorumn,etc.According to the drug cluster,the commonly used core prescriptions were summarized as Zhisou powder,Yinqiao powder,Maxingshigan decoction,Erchen decoction,etc. |
