Genetic Association Between Lipoprotein Lipase Gene Polymorphism And Risk Of Atherosclerotic Cerebral Infarction In Elderly Patients With Hypertension

Objective:To inquire into the genetic association between rs264 polymorphism of lipoprotein lipase(LPL)gene and the risk of large atherosclerotic cerebral infarction in elderly patients with hypertension.Methods:A total of 130 hypertension patients with atherosclerotic cerebral infarction in the Hospital were selected as the case group,and 260 hypertension patients with age and sex matching were selected as the control group.LPL rs264 polymorphism was classified by PCR,and genetic balance was tested by Hardy-Weinberg law.Logistic regression was used to analyze the genetic association between LPL gene polymorphism and major atherosclerotic cerebral infarction.Results:The proportions of diabetes,hyperlipidemia,coronary heart disease,smoking and drinking in the case group were significantly higher than those in the control group(P<0.01).There was a statistically significant difference in the frequency of AA,AG,and GG genotypes at the rs264 locus between the two groups(P<0.05).There was a statistically significant difference in the frequency distribution of A,G alleles at the rs264 locus between the two groups(OR=1.559,95%CI: 1.117～2.176,P=0.010).Logistic regression analysis showed that the GG genotype at rs264 locus was significantly associated with the incidence of atherosclerotic cerebral infarction in hypertensive patients(OR=0.248,95%CI: 0.106～0.582,P=0.001).BMI,diabetes,hyperlipidemia,coronary heart disease,smoking and drinking were also risk factors of atherosclerotic cerebral infarction in hypertensive patients(P<0.05).Conclusion:LPL rs264 gene polymorphism may be associated with the incidence of large atherosclerotic cerebral infarction in elderly hypertensive patients and may be an effective genetic factor for risk prediction.