Development Of Intelligent "Living" Materials Based On Bacteria And Their Applications In Movement Disorders

Bacterial therapy has great application prospects in the field of biomedicine,but the uncontrollability of bacteria in animals and the pressure of the external environment limit the application of bacteria in diseases.The smart bacteria modified by nanomodification can control the metabolism of bacteria through special stimulation in vitro or specific environmental changes in vivo.It has the advantage of controllable time and space,avoiding the uncontrollable and easy removal of bacteria in vivo,and improving the bacteria in vivo.Application safety and effectiveness of disease treatment.This article develops a variety of intelligent “living” materials for bacteria to synthesize small-molecule drugs with nanometer internally modified bacteria and nanometer externally modified bacteria,and discusses its preliminary biomedical applications in diseases that cause movement disorders.First,cyanobacteria micro-nano devices are prepared by internally modifying cyanobacteria by up-conversion nanoparticles(UCNPs).This device can emit blue light under the irradiation of Near-infrared light(NIR)and provide it to cyanobacteria.Perform photosynthesis to produce oxygen.The use of up-conversion nanoparticles introduces near-infrared light,which solves the problem of shallow penetration of blue light through tissues and high toxicity.In addition,the use of near-infrared light improves the temporal and spatial controllability of the cyanobacteria micro-nano device,and near-infrared light can trigger the cyanobacteria micro-nano device to produce oxygen.Secondly,nano-externally modified bacteria can controllably synthesize small molecule drugs for the treatment of diseases that cause movement disorders.Due to the direct oral administration of probiotics,there is a problem that the digestive juice damages the bacteria and releases drugs in non-destination.We use nano-copolymer surface modification probiotics to prepare a bionic dormant body to improve the resistance of probiotics to gastrointestinal fluids.At the same time,the bionic dormant body can wake up intelligently in the intestine and improve the time and space of probiotics in the intestine to synthesize drugs.Controllability.Cyanobacteria micro-nano devices and probiotics biomimetic dormant bodies synthesize small molecule drugs in the body through time and space controllable nano-internal and external modifications for the treatment of exerciserelated diseases such as rheumatoid arthritis(RA)and Parkinson’s disease(PD).In summary,the nano-internal and external modification based on bacterial “living”materials constructed in this paper has achieved preliminary effects in diseases that cause movement disorders,and provides an important reference for the further optimization and improvement of bacterial treatment of diseases that cause movement disorders.