The Related Analysis Between TSH And Metabolic Indicators Including Serum Lipids,Fasting Plasma Glucose In Children And Adolescents With Mental Disorders

ObjectiveThis article aims to determine the prevalence of thyroid stimulating hormone(TSH)in children and adolescents with mental disorders.Meanwhile to explore relationship between TSH and other metabolic indexes including total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),hemoglobin A1c(Hb A1c),uric acid(UA),cystatin C(Cys C),and body mass index(BMI)in female patients with depression,the thesis will provide theoretical support for clinical practice.Methods2003 hospitalized adolescents with mental disorders were included in the affiliated brain Hospital of Guangzhou Medical University from 2018 to 2020.Basic demographic information,diagnosis at discharge,BMI,lipid metabolism,FPG,Hb A1 c,UA,Cys C,and thyroid function test results were collected.Differences between groups were compared through one-way ANOVA.In addition,Pearson correlation analysis,linear regression analysis and binary logistic regression analysis were used to assess the impact of TSH on above metabolism indicators in female patients with depression.All data were analyzed using SPSS software version 26.Results(1)In this study,the incidence of TSH abnormalities in adolescents with mental disorders was 5.5%(109/2003),3.3%(n=66)low(TSH<0.35 m IU/L),and2.2%(n=43)elevated(TSH>4.94 m IU/L).In addition,the incidence of TSH abnormalities in patients with bipolar disorder was 7.6%(48/635),4.4%(34/763)in patients with depression,3.9%(12/312)in patients with schizophrenia,and 4.6%(13/293)in patients with other mental disorders.(2)In the Pearson correlation analysis,TC,TG,and LDL-C were positivel y associated with TSH in all female patients with depression.TG were positive ly associated with TSH in children patients group.TC,TC and BMI were posit ively associated with TSH in adolescents patients group.(3)In the linear regression analysis,TG were positively correlated with TSH in all female patients with depression(P<0.05).There were linear positive correlations between TG and TSH in children group(P<0.05).There were positive linear correlations between TC,TG and TSH in adolescents group(P<0.05).(4)In the logistic regression analysis,TG was associated with an increased risk of TSH elevated in all female patients with depression(OR =3.751,P<0.05)and in children group(OR =5.414,P<0.05).ConclusionsThe incidence of TSH abnormalities in adolescents with mental disorders in this study was 5.5%,with low TSH levels of 3.3%,and elevated TSH levels of 2.2%.The incidence of TSH abnormalities in patients with bipolar disorder is 7.6%,4.4%in patients with depression,3.9% in patients with schizophrenia,and 4.6% in patients with other mental disorders.TG were positively correlated with TSH in all female patients with depression(P<0.05).TG was associated with an increased risk of TSH elevated in all female patients with depression.