Clinical Study Of Probiotics In The Adjuvant Treatment Of Non-Alcoholic Fatty Liver Disease

Objective:To observe the clinical effect of probiotics in the treatment of non-alcoholic fatty liver disease.Method:In this study,86 patients diagnosed with non-alcoholic fatty liver disease admitted to the First Affiliated Hospital of Hebei North University from December 2020 to April 2022 were selected and divided into control group（43 cases）and observation group（43 cases）according to the principle of randomized control.Control group:oral silybin capsule 105mg/time,3times/day;Observation group:on the basis of control group,bifidobacterium lactobacillus triple viable tablet was combined with bifidobacterium 2g/time,3 times/day,all subjects were given diet management and exercise guidance,the course of disease was 6 months,and the efficacy and adverse reactions were evaluated after treatment.Efficacy indicators included alanine aminotransferase（ALT）,asoxalacetic aminotransferase（AST）,cholesterol（TC）,triglyceride（TG）,interleukin-10（IL-10）,interleukin-17（IL-17）,hyaluronidase（HA）,laminin（LN）,type III procollagen（PC-III）,type IV collagen（PC-IV）)and improvement before and after liver color ultrasound treatment.During the telephone follow-up,the serious adverse reactions found in the instructions were recorded.Results:1.After treatment,ALT of observation group and control group was（57.24±24.83）and（73.56±26.82）U.L^-1,AST was（34.29±11.15）and（54.83±17.16）U.L^-1,TC was（2.89±0.55）and（3.82±0.70）mmol.L^-1,TG was（1.67±0.42）and（2.02±0.37）mmol.L^-1,IL-17 was（16.71±1.77）and（21.83±3.40）ug.L^-1,IL-10 was（20.48±4.10）and（16.35±3.20）ug.L^-1,The difference was statistically significant（P<0.05）.2.Posttreatment,HA,LN,PC-III and PC-IV were decreased in 2 groups,and the control group was higher than the observation group,the results was significant（P<0.05）.3.Posttreatment,the batterment of fatty liver in both groups was more significant in the observation group than in the control group（χ²=9.074,P<0.05）.4.The total effective rate was 95.12%in the observation group and76.19%in the control group.The total efficient proportion of the observation group was higher than that of the control group（χ²=6.012,P<0.05）.5.One patient in the control group withdrew due to severe diarrhea,while no adverse reactions occurred in the observation group,but two patients withdrew due to subjective reasons.Conclusion:Probiotics combined with silybin group showed more obvious improvement in liver enzymes,blood lipids,inflammatory factors,liver fibrosis indexes and the degree of liver fatty liver in patients with no increase in adverse reactions.Therefore,probiotics have become a potential treatment for NAFLD.