Effect Of NF-κB Factor On The Phase Of Microangiopathy In Type 2 Diabetic Patients With Different TIR Relationship Research

Objective(s): To collect the age,sex,time in range,TIR)of glucose,renal function,urinary microalbumin,fundus examination of type 2 diabetic patients who have worn the ambulatory blood glucose monitor,and collect their serum to detect NF-κB factor concentration on the premise of signing informed consent.To analyze whether the differences of NF-κB factor,renal function,urinary microalbumin and fundus examination in patients with type 2 diabetes mellitus with different TIR have statistical and clinical significance.To explore the serum NF-κB factor concentration in patients with type 2 diabetes and the correlation between diabetic microangiopathy and TIR.Methods: This study has been reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Kunming Medical University(Shen-PJ-Ke-2022-113)after signing the informed consent form.1.Collect 80 patients with type 2 diabetes who were hospitalized in the Endocrine Department of the Second Affiliated Hospital of Kunming Medical University from September 2022 to November 2022 and wore CGM with complete diagnostic information.2.Divide the patients into three groups according to their TIR,among which there are 32 cases in group A(TIR≦30%),17 cases are male,15 cases,aged 51.461±0.62 years;group B(70%>TIR>30%)27 cases,14 males,13 females,aged 61.22±13.33 years;group C(TIR≧70%)21 cases,12 males,9 females,age 55.71±12.98 years.3.After signing the informed consent,the serum of three groups of patients in different TIR groups was collected and analyzed.ELASA was used to detect the concentration of NF-κB factor.The data of the three groups were analyzed by ANOVA or rank The sum test was used to compare the age,gender,renal function,urine microalbumin,fundus lesions,NF-κB factor concentration among the three groups.Degree,and using the LSD-T test and Bonferroni test for pairwise comparisons.4.Normal for both variables The distributed data uses Pearson correlation analysis to analyze whether the two have correlation,and for one of them For data with skewed distribution of variables,Spearman correlation analysis was used.Results: 1.Comparison among the three groups: Group B was older than the other two groups,and the difference was statistically significant(P<0.05),while the difference in gender and disease course was not statistically significant(P>0.05).2.Comparison among the three groups: TG and Hb A1 c in Group A were higher than those in the other two groups,with significant statistical significance(P<0.01).However,there was no statistically significant difference in TC,HDL-C,LDL-C,NONHDL,ALT,AST,TBIL,DBIL,IBIL,CK among the three groups(P>0.05).3.There was no statistically significant difference in urea,uric acid,and urinary creatinine among the three groups(P>0.05).4.There was no significant difference in fundus lesions of diabetes among the three groups(P>0.05).5.NF of Group A-κ The concentration of B was significantly higher than the other two groups,and the difference was statistically significant(P<0.01)-κ The concentration of B was higher than that of C group,and the difference was statistically significant(P<0.05).6.Three sets of TIR and NF-κ B was negatively correlated(r=-0.642,P<0.01),TIR was positively correlated with e GFR(r=0.738,P<0.01),and TIR was negatively correlated with UACR(r=-0.301,P<0.01).6.There was no correlation between TIR and urea,blood creatinine,uric acid,urine creatinine,and whether there was fundus disease among the three groups.7.Pearson correlation analysis between NF-KB concentration and renal function among the three groups showed that NF-κ The concentration of B was positively correlated with UACR(r=0.243,P<0.05)levels,and negatively correlated with e GFR levels(r=-0.43,P<0.01).It was not correlated with blood creatinine,uric acid,urea,urine creatinine,and urine microalbumin levels(P>0.05).8.NF between three groups-κ B was positively correlated with diabetes nephropathy(r=0.614,P<0.01).Conclusion(s):The TIR of type 1.2 diabetes patients was positively correlated with e GFR and negatively correlated with UACR;2.NF in patients with type 2diabetes-κ The concentration of B is positively correlated with UACR levels,and negatively correlated with TIR and e GFR levels.3.In different TIR groups,NF-κThe concentration of B is positively correlated with diabetes nephropathy.