| Objective(s):Chemotherapy-induced nausea and vomiting(CINV)is one of the most common and distressing adverse reactions in cancer patients undergoing chemotherapy.The use of antiemetic drugs prior to the administration of antitumor drugs is the key to preventing CINV.Even with the use of prophylactic antiemetic drugs,CINV remains a problem that plagues cancer patients.This study intends to explore whether short-term web-based mindfulness-based cognitive intervention can be used as a complementary therapy before chemotherapy in combination with antiemetic drugs to better prevent the occurrence of CINV.Methods:The study population were 118 inpatients with pathologically confirmed malignant tumors who were about to received either moderately or highly emetogenic chemotherapy for the first time were randomly assigned to 2 groups before treatment.The control group was given pre-chemotherapy education plus prophylactic antiemetic drugs,and the experimental group was given short-term web-based mindfulness-based cognitive intervention based on the control group(the mindfulness intervention started from the first day of chemotherapy to the end of the fourth day after chemotherapy).Considering that age,gender,anxiety,and depression are potential risk factors for CINV in cancer chemotherapy patients,the patient’s risk factors were collected prior to intervention,and the baseline mental state was evaluated by self-rating anxiety scale(SAS)and self-rating depression scale(SDS).After the intervention,MASCC antiemetic evaluation tool(MAT)was used to evaluate the occurrence of nausea were used to evaluate the baseline mental state of patients before intervention.and vomiting and the severity grading of nausea and vomiting after chemotherapy.And statistical analysis of the post-intervention results in both groups assessing the impact of short-term web-based mindfulness-based cognitive therapy on CINV.Results:1.The incidence of CINV in the experimental group was lower than that in the control group,with incidence of 32.6% and 63.8% respectively,and the difference was statistically significant(P < 0.05).2.The incidence of acute nausea,acute vomiting,delayed nausea and delayed vomiting in the experimental groups were lower than those in the control group,with incidence of 4.3% vs.31.9%(P < 0.001),2.2% vs.17.0%(P < 0.05),30.4% vs.48.9%(P > 0.05),15.2% vs.19.1%(P > 0.05),respectively.The difference in acute phase was statistically significant,but the difference in delayed phase was not statistically significant.3.The incidence of nausea was higher than vomiting in two groups.The incidence of CINV in the delayed stage was higher than in the acute stage in two groups(incidence of nausea and vomiting in acute stage was 18.3% and 9.7%,and delayed stage was 39.8% and 17.2%,respectively).4.The grade of nausea and vomiting in the experimental group was lower than in the control group.The proportion of acute nausea in the experimental group was50.0% in grade 1 and 50.0% in grade 2,and the proportion of acute nausea in the control group was 46.7% in grade 1 and 53.3% in grade 2,the difference was statistically significant(P < 0.001).Acute vomiting in the experimental group was grade 1,and the proportion of acute vomiting in the control group was grade 1(50.0%),grade 2(25.0%),and grade 3(25.0%),and the difference was statistically significant(P < 0.05).The proportion of delayed nausea in each grade in the experimental group was 42.9% in grade 1 and 57.1% in grade 2,and the proportion of delayed nausea in each grade in the control group was 30.4% in grade 1 and 69.8% in grade 2,with no significant difference(P > 0.05).The proportion of delayed vomiting in each grade in the experimental group was 14.3% in grade 1,57.1% in grade 2,and28.6% in grade 3.The proportion of delayed vomiting in each grade in the control group was 22.2% in grade 1,44.2% in grade 2,and 33.3% in grade 3,with no significant difference(P > 0.05).5.Univariate and multivariate analysis of the influence of potential risk factors and antiemetic treatment related factors on CINV indicated that gender,intervention mode,and antiemetic drugs were influencing factors of CINV,and the difference was statistically significant.Conclusion(s):1.Among all patients with CINV,the incidence of nausea was higher than that of vomiting.2.Among all patients with CINV,the incidence of delayed CINV was higher than that of acute CINV.3.The incidence and grade of total CINV,acute CINV,and delayed CINV in the experimental group were lower than those in the control group,suggesting that the short-term web-based mindfulness-based cognitive intervention may be used as a complementary therapy for CINV,and combining antiemetic drugs may reduce the incidence and severity of CINV.4.The incidence and severity of delayed CINV in the experimental group were lower than those in the control group,but the difference was not statistically significant.Therefore,the effect of short-term web-based mindfulness-based cognitive intervention on delayed CINV needs to be further investigated. |
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