Clinical Study On The Treatment Of Gastrointestinal Dysfunction In Sepsis With Appetizer Sou

Objective: In this study,under the guidance of the spleen and stomach,Xingpi and Xiaoshi therapy,we planned to use Kaiwei Jinshitang(KWJST)decoction to treat sepsis gastrointestinal dysfunction(Sepsis Gastrointestinal Dysfunction,SGD)syndrome of spleen and stomach weakness,and to observe its effect on sepsis gastrointestinal dysfunction.Functional recovery and impact on inflammatory responses.Methods: SGD patients with spleen and stomach weakness syndrome were randomly divided into control group and observation group,30 cases in each group,1 case in the control group dropped out/kicked out,29 cases were retained,2 cases in the observation group dropped out/kicked out,28 cases were retained,and the final 57 cases were patients completed this study.The control group was given gastrointestinal conditioning treatment on the basis of the routine treatment of sepsis;the observation group was given KWJST decoction on the basis of the control group,and the course of treatment was 7 days.SOFA,APACHE II and GCS scores were used to evaluate the prognosis of sepsis;GIF score,AGI classification,gastrointestinal dysfunction score,bowel sound score,and intra-abdominal pressure were used to evaluate gastrointestinal function;inflammatory response and TCM syndromes were compared in patients with SGD before and after treatment Finally,the efficacy and safety were evaluated.Results: After treatment,the scores of SOFA,APACHE II,GIF,AGI,gastrointestinal dysfunction,bowel sounds and intraperitoneal pressure in the control group and the observation group decreased,and the GCS score increased.After treatment,the scores of SOFA(P < 0.01),APACHE II(P < 0.01),GIF(P < 0.01),AGI(P < 0.05),gastrointestinal dysfunction(P < 0.01),bowel sounds(P < 0.05)and intraperitoneal pressure(P < 0.01)in the observation group decreased compared with those in the control group,But the GCS(P< 0.01)score did not increase significantly.PCT,hs CRP,WBC and NEUT% decreased in the control group and the observation group after treatment;After treatment,PCT,hs CRP,WBC and NEUT% in the observation group were lower than those in the control group.After treatment,the scores of sofa(P < 0.01),APACHE II(P < 0.01),GIF(P < 0.01),AGI(P <0.01),gastrointestinal dysfunction(P < 0.01),bowel sounds(P < 0.05),intraperitoneal pressure(P < 0.01)and GCS(P < 0.01)in the control group and the observation group decreased,and the scores of sofa(P < 0.05),APACHE II(P < 0.05),GIF(P < 0.01),AGI(P< 0.05)and Gastrointestinal dysfunction score(P < 0.05),bowel sounds score(P < 0.05)and intraperitoneal pressure(P < 0.01)were lower than those in the control group,but GCS score(P > 0.05)did not increase significantly.PCT(P < 0.01),hs CRP(P < 0.01),WBC(P< 0.01)and NEUT%(P < 0.01)decreased in the control group and the observation group after treatment;After treatment,PCT(P < 0.01),hs CRP(P < 0.05),WBC(P < 0.01)and NEUT%(P < 0.01)in the observation group were lower than those in the control group.The score of TCM syndrome in the control group and the observation group decreased significantly after treatment(P < 0.01),and the score of TCM syndrome in the observation group decreased significantly after treatment(P < 0.01).Conclusion: On the basis of conventional treatment,Kaiwei Jinshitang can better reduce the inflammatory response of SGD patients,improve the gastrointestinal function,and effectively improve the prognosis,which provides a clinical basis for the treatment of SGD with integrated traditional Chinese and Western medicine.