| Background:Breast Cancer(BC)is the most common type of cancer in women worldwide,but with its mortality decreasing and survival gradually increasing,a proportion of BC patients require a long course of treatment.The long-term management of BC patients is associated with different chronic diseases,among which Thyroid Diseases(TD)are more common and are suspected to have an impact on the development of breast cancer.However,there are different opinions about the relationship between thyroid diseases and breast cancer,and no consensus has been reached between Chinese and Western medicine,so it is especially important to understand the relationship and reduce the complications.Objective:To investigate the correlation between breast cancer and thyroid disease and the consititution characteristics of Traditional Chinese Medicine(TCM),in order to provide a reference for the long-term treatment and management process of breast cancer by TCM.Methods:A cross-sectional study was conducted to collect clinical data of breast cancer patients attending the outpatient clinic of the Department of Oncology,Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine from January 2022 to March 2023,to investigate the thyroid condition of-the patients,and to investigate their TCM constitution according to the TCM constitution classification and determination table,to analyze and compare the effect of combined thyroid disease on the TCM constitution of breast cancer patients,and.to use logistic regression analysis to explore the influencing factors related to the occurrence of thyroid lesions in breast cancer patients.Results:(1)167 breast cancer patients were included,73 with combined thyroid disease and 94 with simple breast cancer.The prevalence of thyroid disease in breast cancer patients was 43.7%,and all thyroid diseases occurred were structural thyroid lesions.(2)The distribution of age,fertility status,body mass index(BMI),nuclear proliferation antigen(ki67)and estrogen receptor(ER)differed between patients with combined thyroid disease and those with breast cancer alone;regression analysis showed that ER,Her-2 and Ki-67 were correlated with the development of thyroid lesions in breast cancer,with ER positivity(OR=2.642 95%CI 1.184-5.897),Her-2 positive(OR=2.831 95%CI 1.277-6.276),and high Ki-67 values(OR=2.437.95%CI 1.224-4.851)as risk factors for thyroid lesions in breast cancer(P<0.05).(3)The TCM constitution of breast cancer patients with combined thyroid disease were:28 cases(16.8%)with qi yu,9 cases(5.3%)with qi deficiency,8 cases(4.8%)with yin deficiency,7 cases(4.2%)with yang deficiency,8 cases(4.8%)with phlegm damp,3 cases(1.8%)with damp heat,4 cases(2.4%)with blood stasis,3 cases(1.8%)with pinghe,and 3 cases(1.8%)with special endowment.1.8%);in the simple breast cancer group,37 cases(22.2%)were of qi-yu quality,12 cases(7.1%)were of qi-vacant quality,10 cases(6.0%)were of yin-vacant quality,10 cases(6.0%)were of yang-vacant quality,8 cases(4.8%)were of phlegm-damp quality,6 cases(3.6%)were of damp-heat quality,5 cases(3.0%)were of blood-stasis quality,4 cases(2.4%)were of ping-he quality,and 2 cases(1.2%)were of special endowment quality.1.2%).The analysis of variance suggested that there was no difference in the distribution of TCM constitution between breast cancer patients with combined thyroid disease and breast cancer patients alone(P>0.05),and the regression analysis showed no correlation between combined thyroid disease and TCM constitution of breast cancer patients(P>0.05).Conclusions:(1)Positive ER and Her-2 expression and high Ki-67(>30%)in breast cancer patients may be associated risk factors for combined thyroid disease in breast cancer patients;.(2)The TCM constitution of breast cancer patients with combined thyroid disease was dominated by Qi-yu constitution,followed by Qi-vacant,Yin-vacant,and Yang-vacant constitutions. |
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