| Objective : Through investigation and research,summarizing the types of susceptible TCM constitutions and risk factors associated with female breast cancer patients in Shanxi area,exploring the prevention strategies for breast cancer in this area,and providing theoretical basis for breast cancer prevention and treatment in this area.Method:300 women with newly diagnosed breast cancer and 300 women with physical examination in the same period in outpatient and inpatient departments of three Class-A hospitals in Taiyuan city were studied.Investigators conducted face-to-face questionnaire survey and TCM constitution type judgment for the included researchers,and sorted out the survey data.According to the data obtained,binary logistic regression analysis was carried out for the related data of TCM Constitution;single factor analysis was carried out for the related risk factors,and those with statistical significance entered the multi factor Logistic regression analysis.At the same time,taking menopause as stratified variable,the stratified analysis was carried out.Statistical methods were used to analyze and compare the risk factors of the two groups and the distribution rule and difference of TCM Constitution.The correlation between them and breast cancer was determined by regression analysis.Results:1.There was no significant difference in age between the two groups;BMI(P = 0.016)and marital status between the two groups(P = 0.003),animal meat(P = 0.011),fruit(P = 0.000),soy products(P = 0.040),fried food(P = 0.016),alcohol(P = 0.017),menarche year(P < 0.001),menopause(P = 0.014),abortion times(P = 0.001),breast hyperplasia(P = 0.027),nipple discharge(P = 0.010),family history of breast cancer(P < 0.001),mental stress(P < 0.001),birth There was a significant difference in the composition of stored pressure(P = 0.026)and HAMA score(P < 0.001).2.The constitution of traditional Chinese medicine related to breast cancer includes the quality of peace(P < 0.001),the quality of qi deficiency(P = 0.003),the quality of qi depression(P < 0.001),the quality of Yang deficiency(P = 0.003)and the quality of phlegm dampness(P = 0.005).Among them,the peacefulness(OR = 0.061)was the protective factor of breast cancer in this area.In the biased constitution,Qi Stagnation(or = 2.902),Qi deficiency(or = 2.980),Yang deficiency(or = 2.410)and phlegm dampness(or = 2.005)are the susceptible and dangerous constitution of breast cancer.3.The constitution of TCM in the premenopausal group was composed of Pinghe(P < 0.001),Qiyu(P = 0.001),blood stasis(P = 0.015)and phlegm dampness(P = 0.010).Among them,peacefulness(OR = 0.061)is the protective factor of breast cancer in premenopausal women.In the biased constitution,Qi Stagnation(OR = 2.585),blood stasis(OR = 2.638)and phlegm dampness(OR = 2.103)are the predisposing constitution of the premenopausal women with breast cancer.The constitution of TCM in menopause group was composed of peacefulness(P < 0.001),Qi Stagnation(P = 0.002).4.Analysis of risk factors of undifferentiated breast cancer.Multivariate logistic regression analysis showed that infrequent fruit consumption(OR = 4.74)and Hamilton Depression Scale(OR = 0.25),infrequent drinking(OR = 0.46),menarche age < 14(OR = 0.11),education level: infrequent fried food(OR = 0.13),infrequent sweet food(OR = 0.44)and infrequent sweet food(OR = 0.13)were the relative risk factors of breast cancer in this area Eating(OR = 0.19),drinking tea infrequently(OR = 0.39),never suffering from breast hyperplasia(OR = 0.41),never suffering from nipple discharge(OR = 0.12),and no family history of breast cancer(OR = 0.11)were the relative protective factors of breast cancer in this area.5.The results showed that the risk factors of more miscarriages(OR = 4.067)were the risk factors,while the risk factors of breast cancer were the non frequent consumption of livestock meat(OR = 0.03),the non frequent consumption of fried food(OR = 0.02),the non occurrence of breast hyperplasia(OR = 0.19),the absence of family history of breast cancer(OR = 0.03),the acceptable range of survival pressure(OR = 0.45),and the Hamilton Depression scale value greater than 21.The risk factors of breast cancer in postmenopausal women were analyzed by multivariate logistic regression analysis.The results showed that infrequently eating fruits(OR = 2.95),infrequently eating soy products(OR = 3.67),Hamilton Depression Scale(OR = 21)were the risk factors of breast cancer,while infrequently eating livestock meat(OR = 0.45),infrequently eating fried food(OR = 0.18),infrequently eating sweets(OR = 0.14)were the protective factors of breast cancer.Conclusion:1.There are differences in TCM Constitution Types and risk factors before and after menopause in women with breast cancer in Shanxi.2.The female breast cancer in Shanxi Province has a predisposing constitution.Among them,qi stagnation quality,Yang deficiency quality,Qi deficiency quality and phlegm dampness quality have higher risk of breast cancer than those of other constitution;the peaceful quality is the protective constitution of breast cancer.3.The risk factors of female breast cancer in Shanxi Province mainly include: eating meat of domestic animals,fried food,sweet food,drinking,abortion,nipple discharge,family history of breast cancer,high Hamilton Depression Scale.BMI < 24,menarche age < 14,education level: junior high school students are compared with postgraduates,and fruit is milk The protective factors of adenocarcinoma. |
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