Effect Of Buyang Huanwu Decoction On Cerebral Perfusion In Basal Ganglia-Thalamus Region Intracerebral Hemorrhag

Objective: To observe the effect of Buyang Huanwu Decoction on cerebral blood flow perfusion in patients with basal ganglia thalamus hemorrhage of qi deficiency and blood stasis type after catheter drainage.Method:From January 2021 to January 2023,80 patients with basal ganglia thalamic intracerebral hemorrhage in the Department of Neurosurgery of Hunan Provincial Brain Hospital(the second people’s Hospital of Hunan Province)were treated with hematoma cavity drainage and intracranial pressure probe implantation within 12 hours after admission.After operation,they were randomly assigned to the experimental group and the control group,40 cases in each group.The experimental group was treated with Buyang Huanwu Decoction 72 hours after operation,twice a day for 14 days.The cerebral blood flow of the patients in the two groups was observed by magnetic resonance perfusion weighted imaging(MRI-PWI)on the 7th and 14 th day after taking medicine.The changes of NIHSS score,TCM syndrome score,Glasgow Coma Score(GCS)and Glasgow Outcome Score(GOS)in the two groups before taking medicine,on the 7th and 14 th day after taking medicine were observed.Results:1.There were no significant differences in age,gender,average arterial pressure,initial hematoma volume,hematoma side,average operation time and residual hematoma volume at 72 hours after operation between the two groups(P>0.05),which were comparable.2.Cerebral blood flow perfusion of patients in the two groups: on the 7th day after taking medicine,the local cerebral blood flow(r CBF)and regional cerebral blood volume(r CBV)of patients in the two groups increased,and the mean transit time(MTT)and time to peak(TTP)decreased.The increase of r CBF and r CBV in the experimental group was more significant than that in the control group(P<0.05),and the decrease of MTT and TTP in the experimental group was more significant than that in the control group(P<0.05).On the 14 th day after taking the medicine: the r CBF and r CBV of the two groups were increased,and the MTT and TTP were decreased.The increase of r CBF and r CBV in the experimental group was more significant than that in the control group(P<0.05),and the decrease of MTT and TTP in the experimental group was more significant than that in the control group(P<0.05).3.NIHSS score of the two groups: before taking medicine,there was no significant difference in NIHSS score between the two groups(P>0.05).On the 7th day after taking the medicine,the NIHSS score of the two groups decreased(P<0.05),and the NIHSS score of the experimental group decreased more significantly than that of the control group(P<0.05).On the 14 th day after taking the medicine,the NIHSS score of the two groups decreased further than that of the control group(P<0.05),and the NIHSS score of the experimental group decreased more significantly than that of the control group(P<0.05).4.GCS score of the two groups: before taking medicine,there was no significant difference in GCS score between the two groups(P>0.05).On the 7th day after taking the medicine,the GCS score of the two groups decreased(P<0.05),and the GCS score of the experimental group decreased more significantly than that of the control group(P<0.05).On the 14 th day after taking the medicine: the GCS scores of the two groups were significantly lower than those of the control group(P<0.05),and the GCS scores of the experimental group were significantly lower than those of the control group(P<0.05).5.TCM syndrome score of the two groups: before taking medicine,there was no significant difference in TCM syndrome score between the two groups(P>0.05).On the 7th day after taking medicine,the TCM syndrome scores of the two groups were decreased(P<0.05),and the decrease of TCM syndrome scores in the experimental group was more significant than that in the control group(P<0.05).On the 14 th day after taking the medicine: the TCM syndrome score of the two groups decreased further than that of the control group(P<0.05),and the TCM syndrome score of the experimental group decreased more significantly than that of the control group(P<0.05).6.GOS score of the two groups: after treatment,the GOS score of the experimental group increased more significantly than that of the control group(P<0.05).Conclusion:The application of Buyang Huanwu Decoction in patients with cerebral hemorrhage in basal ganglia thalamus region can promote the absorption of hematoma,improve the cerebral blood flow perfusion in the peripheral area of hematoma,and restore the neurological function of patients,which is conducive to improving the TCM syndrome and prognosis of patients.