Clinical Retrospective Analysis Of 60 Cases Of Erythrodermic Psoriasi

Objective: By analyzing the general information,clinical manifestations,and laboratory data results of hospitalized patients with erythrodermic psoriasis,this study aims to explore the relationship and differences between the two syndrome types of fire toxin hyperactivity syndrome and fire toxin injury yin syndrome,providing guidance for clinical syndrome differentiation and treatment.At the same time,further understand the situation of erythrodermic psoriasis with comorbidities,explore the influencing factors of erythrodermic psoriasis with comorbidities,and provide reference basis for its clinical prevention and treatment.Materials and Methods:The medical records of 60 patients with erythrodermic psoriasis who were first treated in the dermatology ward of our hospital from January1,2010 to December 31,2022 were collected,including general data(gender,age,onset season,course of disease,length of hospitalization,pathogenic factors,smoking and drinking history,family history,etc.),clinical manifestations(onset site,accompanying symptoms),laboratory examination results,etc,Perform statistical analysis on the collected data by applying SPSS26.0 software.Results:1.General information: Among the 60 patients,the male to female ratio is 2.5:1.The average age of patients is 53.05 ± 18.29 years old,with the highest number of patients aged ≥ 60 years old.The number of cases in spring and summer seasons is equal to that in autumn and winter seasons.The average duration of the patient’s progression from primary psoriasis to EP was 15.65 ± 14.01 years,and the average hospital stay was 14.47 ± 4.67 days.The main causes of this outbreak are upper respiratory tract infection(7 cases)and drug abuse(6 cases).18 patients had a history of smoking,and 7 patients mentioned a history of drinking alcohol.There was no significant difference(P>0.05)in general information between patients with fiery and toxic yin syndrome and those with fiery and toxic yin syndrome.2.Clinical manifestations: The main affected areas of the patient include 60 limbs,59 trunk,46 scalp,37 face,33 hands,25 feet,and 24 nails.The accompanying symptoms mainly include 50 cases of obvious exudation and edema,46 cases of itching,16 cases of fever,15 cases of lower limb edema,9 cases of palmoplantar keratosis,4cases of joint pain,and 2 cases of superficial lymph node enlargement.There is no significant difference in clinical manifestations between the syndrome of excessive fire and toxin and the syndrome of yin damage caused by fire and toxin(P>0.05).3.Laboratory examination results: Blood routine examination showed an increase in white blood cell count in 8 cases,an increase in neutrophil count in 8 cases,an increase in eosinophil count in 6 cases,and an increase in C-reactive protein in 25cases;Liver function: 25 cases had a decrease in total protein and 11 cases had abnormal liver enzymes;Renal function: creatinine decreased in 7 cases and uric acid increased in 18 cases;Lipids: 7 cases had an increase in total cholesterol,8 cases had an increase in triglycerides,14 cases had a decrease in HDL,and 5 cases had an increase in LDL;25 cases of abnormal blood sugar,42 cases of abnormal humoral immunity;Other: 6 cases had decreased blood calcium.There is a significant difference(P<0.05)in humoral immune tests between patients with the burning fire and toxin syndrome and those with the burning fire and toxin yin syndrome.4.Comorbidity analysis: 36 patients had comorbidities,while 24 patients did not.Among them,there were 21 cardiovascular diseases,16 endocrine and metabolic diseases,12 liver and kidney diseases,0 immune system diseases,1 psychological disease,and 6 other diseases.There was no significant difference(P>0.05)in whether there were comorbidities between patients with the burning fire and toxin syndrome and those with the burning fire and toxin yin syndrome.Through binary logistic regression analysis,it was found that age>40 years old,smoking history,and abnormal blood sugar were independent influencing factors for EP induced comorbidities(P<0.05).Conclusion :1.The main population of EP patients is middle-aged and elderly men,among which upper respiratory tract infections and drug abuse may be the main inducing factors for EP.2.There is a significant difference in humoral immunity between EP patients with excessive fire and toxin syndrome and EP patients with fire and toxin yin syndrome.3.EP patients are more likely to develop cardiovascular diseases,endocrine and metabolic diseases.The risk factors for comorbidities in EP include age>40 years old,smoking history,and abnormal blood sugar.According to.