Ⅰ. Studies On The Inclusion Complex Between β-cyclodextin And Gossypol Ⅱ. Studies On Reactions Of Nitric Oxide With Propargylic Alcohols And Dihydropyrimidinones

This thesis consists of two parts. The first part outlines: (a) the discover, progress, structure, and character of cyclodextrins, (b) the preparation, structure, characterization, and application of β- cyclodextrin inclusion complexes, and (c) the features of the inclusion complex between gossypol (Gos) and p-cyclodextin (CD) in both solution and solid state and its crystalline morphology.In the second part the studies on reactions of nitric oxide (NO) with two types of active hydrogen are concerned. It includes:(a) The significance and roles of NO in biology and the reactions of NO with organic compounds are reviewed.(b) The recent progress of the oxidation of propargylic alcohols is outlined. Our experimental results on the reaction of NO with propargylic alcohols are described. NO selectively oxidizes the hydroxy group of propargylic alcohols to carbonyl group at ambient temperature. We found that a trace of oxygen promoted reactions. Products were identified by HR-MS, MS, IR, ¹H NMR, ¹³C NMR.(c) The nitrosation and properties of N-nitroso compounds are reviewed. Studies on the reaction of NO with dihydropyrimidinone are carried out. We found that NO could nitrosate one of the secondary amino group under the present condition of dihydropyrimidinone in high regiospecificity in high yield. Products were identified by HR-MS, MS, IR, ¹H NMR, ¹³C NMR and 1D NOE. ab initio and DFT calculations were performed for conforming products and deducing the mechanisms for reactions and solvent effects.