| ObjectiveOur paper was designed to explore the differences in original site^histopa-thology and local invasion between transglottic carcinoma and supraglottic carcinoma. Through this study we can expound the position of transglottic carcinoma and decide whether transglottic carcinoma can be regarded as a type of laryngeal carcinoma.MethodsFifty transglottic carcinoma specimens were selected from patiens who were diagnosed as transglottic carcinoma in our hospital from 1984 to 1993, and in operation the main lesions of the turner was proved to lie in the ventricle or originate from the ventricle. Forty - four males and six females were from 37 years old to 80 years old with a history from 6 months to 3 years. Fifteen cases(30% ) suffered tracheotomy before operation. Although biopsy showed negative before operation, eight cases(16% ) were proved to be carcinoma by frozen biopsy in operation. 100 supraglottic carcinoma specimens were selected from patients who were diagnosed as transglottic carcinoma in our hospital from 1988 to 1991, and the main lesions of the tumor lay in the supraglottic region. Fifty - six males and forty - four females were from 39 years old to 78 years old. Eighty - three cases had a history within one year, fifteen cases had a history from 1 year to two years and two cases had a history over two years. Four cases (4% ) suffered tracheotomy before operation. All cases were squamous carcinoma and none accepted any radiotherapy before operation. All the specimens were fixed and then were subjected to whole -organ serial section(25m each section ) ,and then the specimens were subjected to whole - organ serial section, HE staining and microscop-ic observation.ResultsThe main lesion of transglottic carcinoma was in the ventricle or the ventricle was the center of the lesion. Transglottic carcinoma invaded and spreaded in a way that equally involved the supraglottic and glottic regions, the rate of deep submucosal invasion was 52% ( 25/50 ) . The main lesion of supraglottic carcinoma lay in the supraglottic region upper the ventricle. Superficial mucosal invasion with deep submucosal invasion and mucosal invasion were the two major ways of tumor spread, and the rate of the invasion were 43% (43/100) and 38% (38/100) separately. The rate of pre -epiglottic space invasion was 60% (60/100) and the rate of paraglottic space(PGS) invasion was 48% (48/100) in supraglottic carcinoma. In transglottic carcinoma the rate of PGS invasion, which was a symmetrical invasion and 80% (33/41) cases perforated PGS, was 82% (41/50) , and the rate of pre - epiglottic space invasion was 38% ( 19/ 50). In supraglottic carcinoma, the invasion of PGS was non - symmetrical, and the invovled area of super - paraglottic region was larger than that of infer -paraglottic region, which was 79% (38/48) , only 4% (2/48) cases perforated PGS, but no cricothyroid membrane or epiglottic cartilage were involved. In supraglottic carcinoma the pre - epiglottic space was involved in a major way of direct invasion and 70% (42/60) were involved in this way. In transglottic carcinoma the pre - epiglottic space was involved in a major way of indirect invasion which passed the epiglottic stem from PGS, and 74% (14/19) were involved in this way. The rate of epiglottic cartilage invasion was 28% (28/100) in supra-glottic carcinoma, and the rate of thyroid cartilage involved was 52% (26/50) in transglottic carcinoma.ConclusionsThe main lesion of supraglottic carcinoma lies in supraglottic region clearly and takes a typical tumourous appearance, but the ventricle isnt the center of the tumor. The local invasion of supraglottic carcinoma is different from that oftransglottic carcinoma obviously. The tumor mainly invades the epiglottic cartilage. Because the defensive role of the ventricle, the tumor only can invade the paraglottic space non -symmetrically, and that's to say the invasion of super -paraglottic region was larger than that of infer - paraglottic region.The main lesion of transglottic carcin...
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