Clinical Study On The Injury Of 1α Hydroxylase In Renal Tubule Of Hypokalemic Patients With Hyperthyroidism Of Graves' Disease

Objective: To investigate the 1α hydroxylase defect in the renal tubule in hypokalemic hyperthyroid patients with Graves' disease. Methods: To measure serum 25OHD3 and 1,25(OH)2D3 from hypokalemic hyperthyroid patients with Graves disease before and post the intramuscular injection of 300,000 units of vitamin D3. Results: 25OHD3 levels were low in both control group (eukalemic, more than 4.0mmol/L) and hypokalemic group before the treatment. As to 1,25(OH)2D3, the data showed that it was much higher in eukalemic group than that in hypokalemic group before the treatment. On the other hand, however, there was no significant elevation in 1,25(OH)2D3 in hypokalemia while 1,25(OH)2D3 was remarkably elevated instead in the group of eukalemia. Conclusion: There may be a damage to the 1α hydroxylase of renal tubule among those hypokalemic patients with hyperthyroidism of Graves disease. It indicates that the defect be caused by the abnormal autoimmune processes.