Experiment Studies Of Qichou Tang On Mechanisms In Rats Of Chronic Renal Failure

Chronic renal failure (CRF) is damage to kidney which is caused by various kinds of idiopathic or successive renal disease, and the barriers of renal function lead to a series of symptom and kinetic turbulence. The course is slowness but one-way and irrecoverable, and the course of the disease may appear ongoing progress and aggravation, and finally evolve to terminal renal disease (Uraemia).According to the statistics in North America, West Europe and Australia, each year there are 100-150 person per million who suffer from CRF. In our country, referred to the investigation of 2million people city, the incidence of CRF approximately is 568 per million, along with the increase of diabetes, hypertension, the primary affection of CRF, this incidence will gradually rise up.The theory of Chinese medical considered that the occurrence of CRF is correlated with asthenia, turbid, and stagnancy. Qi Chou Tang have a definite effect of CRF which is caused by asthenia of yang of the spleen and kidney, turbid, stagnancy. By using the functions of warm and supplement kidney and spleen, stagnation. In this study we studied on the effect of modern in vivo molecular pharmacology and in vitro serological pharmacology, and explored the mechanism of drug action in molecularlevel. Results: Qi Chou Tang have the function of warm and supplement kidney and spleen, and stagnation; Depress the CRF model which induced by the rats whose kidney cut off largely; Depress BUN, Scr and protect renal functions. Ameliorate the anime of the CRF model rats, depress retrievability hypertrophy of the remains kidney. Decrease the incidence of glomerular cirrhosis, delay the development of CRF. Regulate the turbulence kinetic of lipid. Qi Chou Tang have the functions of decreasing the content of serum CHO, decreasing the volume of the uric protein of rats in 24 hours, reducing lipid deposit in glomerular, and releasing the damage of endothelial and glomerular mesangial. Reduce the damage of tubulointerstitial, reduce the soakage of inflammatory cell and interstitial fibrosis, block or reduce the secretion of TNF a , regulated cytokine , depress the increase of glomerular cell. By decreasing CD11b, CD44 of CRF rats to regulated the expression of leucocyte conglutinae factors, and block the way of glomerular cirrhosis. By using the functions, Qi Chou Tang is applying to clinical widely.