| Objective and Significance:Chronic functional constipation (CFC ) belongs to the category of the constipation of TCM. QI stagnation is most common in CFC, so transferring function of intestines and regulatting the flow of vital energy are the main therapeutic method. but the curative effect of the therapeutic method of TCLQ needs verifying further . The mechanism of happenning on CFC has not been totally expounded yet. Research indicates at present , changes of anorectal manometry is closely related to happenning. Anorectal manometry is more advanced method in recent years to check unusual change of annrectal motility. Many scholar think unusual change of annrectal motility can show changes of rectal sentation functions, annrectal defecate function ,so comparing the curative effect and the change of anorectal manometry is useful to clarify the essence of the syndrome of Qi stagnation and the mechanism of the recipe of DCLQ on treating CFC. Methods:This thesis includes two parts:the literature review and clinical research. Literature review explained from two respects of traditional Chinese and western medicine about concept , pathogenesis , traditionalfunctional mechanism of TCM and annrectal motility of CFC mainly. Clinical research divided into two parts mainly:clinical observing and the reseach of intervention on annrectal motility. Clinical observation adopted at random, by the contrasting principle . The recipe of DCLQ-TiaoChangLiQiTablets(TCLQT) was observing medicine.Maren Capsule(MRC) is contrasting medicine. We divided two groups:35 cases in the observing group was treated by TCLQT and 31 cases in the controlling one was treated by MRC. We mainly observed such respects as symptoms , signs , conditional degree of disease , long-term curative effect before and after treatment of the therapeutic method of TCLQ. The intervening reseach on annrectal motility adopted anorectal manometry to examine the change of rectal sentation functions, annrectal and defecate function of Qi stagtation type of CFC before and after treatment of TCLQT, contrasting by 20 healthy peason. Results:The literature review clarified the present condition of CFC and annrectal motility reseach and found the clue to study the disease.Clinical observation indicated: (1)By the look of overall curative effect, among 35 cases in observing groups, it was 91. 4% to be always effective. Fully the recovering rate was 17.1% among them. The Significantly effective rate was 48.6%. The effective rate was 25. 7%. The ineffective rate was 8.6%; Among Contrasting groups the overall curative effective rate was 80.7%, fully the recovering rate was 6.5% among them. The Significantly effective rate was 29.1%; The effective rate was 45. 2%. The ineffective rate was 19.3%. Dealt with by statistics between two groups(P<0. 05), it had significance difference. Observing group's curative effect was superior to contrasting group's. (2)By the look of the curative effect of the syndromes: Observing group and contrasting group's effect had improvement before and after treating. But the difference of scores for symptoms and signs before and after treatment was also significantly obvious in the observing group than in the contrasting one. The observing group is superior to the contrasting group, dealt with by statistics(P<0.05), there were significance differences. From pointing and solicitting seeing concretly: (1) On respects of clinical main symptom, two groups all made stool properties improve ,Stool number of times increase , defecate time shorten each time after treating, dealt with by statistics, there were significant difference( P <0.05-0. 01). But the observing group was superior to the contrasting group in the improvement of the main symptom, dealt with by statistics (P<0. 05), there were significant differences. (2) By the look from following symptom of constipation , both the observing group and the contrasting one had improvement in various degree in the every following symptom of Qi stagnation syndrome. But the observing group was obviously superior to contrasting the group especially in the well improvement of symptom, such as belchN intestines .Dealt with by statistics (P <0.05), there were significant differences. (3)By the look of respects of these objective index, such as tongue coating and pulse, the observing group was is obviously superior to the contrasting group in the improvement of unusual tongue^ pulse. Dealt with them by statistics (P<0. 05), there were significant differences. (4)On the respect of mprovemeht in the conditional degree of disease, there were significant differences before and after treatment between two groups. Dealt with them by statistics, P<0.05. The observing group was superior to the contrasting group to improve the conditional degree of disease . Dealt with them by statistics (P<0. 05), there were significant differences. (5)In addition, the lighter the conditional degree of disease was, the better the curative effect was; The shorter the course of disease was, the better curative effect was. It showed that annrectal motility intervenes the result of study: these patients of Qi stagnation type of CFC had no unusual anorectal and sphincter pressure, had unusual rectal sentation functions and poor coordination of rectal sphincter of threshold value. It showed that rectal sensation volume thresholds were higher , and rectal maximum tolerable volume thresholds were higher and defecate function was unusal than healthy person. The recipe ofDCLQ-TiaoChangLiQiTablets(TCLQT) could degrade rectal sensation volume thresholds and rectal maximum tolerable volume thresholds after treatment, and could raise harmony of rectal sphincter of threshold value. Dealt with them by statistics (P<0. 05), there were significant differences. Cone I us i ons:Clinical observation is pointed out: the observing group and the...
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