Angiographic Follow-up Study After Cypher And Taxus DES Implantation In Coronary Artery Disease

Backgroud In-stent restenosis is the major limitation hampering the medium-term efficacy of coronary stenting. Recently, several drug-eluting stent (DES) trials have demonstrated a breakthrough in decrease neointimal growth, leading to a marked reduction in late restenosis rates compared with bare metal stents. But the effectiveness of DES in unselected patients treated in the daily practice is currently unknown. The aim of this study was to evaluate the angiographic effect in patients treated with Cypher and Taxus stent implantation in clinical practice.Methods 201 patients with 231 lesions were treated by using 243 rapamycin-eluting stents(Cypher, Cordis, a Johnson & Johnson Company) and 220 patients with 242 lesions by using 278 paclitaxel-eluting stents (Taxus, Boston Scientic). 184 patients underwent angiographic follow-up from 5 to 15 months (98patients in Cypher group, 86 in Taxus group). Follow-up ischemia-driven angiography was performed in 47 ptients (29 patients in Cypher group, 18 in Taxus group).Results After intervention,Pro-In-lesion,In-stent and Dis-In-lesion MLD were 2.78mm,2.49mm and 2.29mm in Cypher group, and 2.56mm, 2.19mm and 2.10mm in Taxus groups. Angiographic follow-up In-stent MLD was larger in the Cypher group than in Taxus group (2.42 vs 2.10mm). But the Pro-In-lesion and Dis-In-lesion MLD were similar in both groups (2.62 vs 2.56mm, 2.20 vs 2.19mm, P=NS). In-stent late loss was lower in the Cypher group than in the Taxus group (0.08 vs 0.37mm P<0.05). The Pro and Dis-Late loss were no differents in two groups (0.17 vs 0.18mm, 0.09 vs 0.12mm,P=NS).Although the restenosis rates and TLR rates were...