Study Of BRCA1 Gene In Hereditary Breast And Ovarian Cancer

Study of BRCAl in hereditary breast and ovarian cancerEpithelial ovarian cancer causes the highest mortality of all gynecological malignancies. The low overall 5-year survival rate of 30% is largely a reflection of the difficulty in diagnosing the disease at an early stage .Most patients are at advanced stage. Breast cancer is one of the most common malignancies in advanced countries. The cumulative incidence of breast cancer is about 10.3% among white female Americans of up to 75 years old. The incidence of breast cancer is increasing in advancing countries. One of the major risk factors for developing either type of cancer is a positive family history of the disease. Approximately 5%-10% of all breast and ovarian cancer is thought to be due an inherited predisposition with the autosomal dominant inheritance of a mutated gene. In the general U.S.and Eruopean,90% of hereditary breast and ovarian cancer can be explained by BRCA1 mutations;50% hereditary breast cancer may be attributed to BRCA1 mutations. The nature of BRCA1 in China is just beginning to be revealed. In this study, We examined germline mutations of the BRCA1 gene in 10 Chinese hereditary breast and ovarian cancer families, 10 early-onset breast cancer(<40 years at diagnosis) and 10 sporadic ovarian cancer, our aim is to understand the involvement of BRCA1 more clearly and tried to reveal four points:...