The Hemodynamic Study Of Viral-induced Cirrhosis And Correlative Hepatic Carcinoma With CT Perfusion

Objective1. To explore the hepatic hemodynamic changes during the transformation from normal liver to viral-induced cirrhosis by using the de-convolution model of CT perfusion.2. To explore the hemodynamic changes of primary hepatic carcinoma(PHC) based on hepatic cirrhosis by using the de-convolution model of CT perfusion. Materials and Methods1. SubjectsOne hundred and twenty cases were sorted into 5 groups: 34 normal controls, 21 cases with viral-induced fibrosis; 27 cases of viral-induced cirrhosis with Child-Pugh A, 23 cases of viral-induced cirrhosis with Child-Pugh B, 15 cases of viral-induced cirrhosis with Child-Pugh C.Thirty-two cases were primary hepatic carcinoma based on viral-induced fibrosis or cirrhosis.Criterion: 'The preventive and therapeutic strategies of viral-induced hepatitis' (instituted on Sept. 2000 ); 'Child-Pugh classification system'; 'The clinic diagnosis and classification of primary hepatic carcinoma'(instituted on Sept. 2001).2. Equipment and contrast mediumLightspeed 16 spinal CT scanner(GE corp. USA) with AW 4.2 workstation for post-processingAn automatic single tube syringe controlled by micro-computer(medrad corp. USA)Nonionic iodinated contrast agent 300mgI/ml3. Examination techniqueRoutine scan: The whole liver was plain scanned by conventional CT with slight...