Investigation Of Etiology And Clinical Characteristics Of 120 Patients Suffered From Primary Hepatic Carcinoma

Objective: To explore etiology and clinical characteristics of primary hepatic carcinoma (PHC) in Hebei province by retrospective analysis of 120 patients suffered from the disease and provide basis for the early diagnosis and treatment.Methods: The clinical data such as hepatitis B virus (HBV) and hepatitis C virus (HCV) markers, alpha-fetoprotein (AFP) as tumor marker, and therapy of 120 patients suffered PHC were analyzed retrospectivley.Results: In the primary hepatic carcinoma patient, infected ratio of HBV and HCV was 83.3% and 7.5%, respectively, and in which only 9.2% experienced antiviral therapy. 20.0% and 6.7% had a family history of liver cirrhosis and liver cancer, respectively. 33.3% had a history of drinking alcohol, and 30.0% smoking. In the HBV infected patients, positive ratio of HBsAg, anti-HBe and anti-HBc was 63.0%, 80.5% were HBV DNA. However, only 41.4% patients were with high HBV DNA level, more than 105 IU/ml. Cirrhosis incidence in the patients with HBV DNA level is higher than those with low HBV DNA level. AFP level was elevated in 69.0% of the PHC patients, in which 34.5% were beyond 400 ng/ml.Conclusions: HBV infection and liver cirrhosis were the important risk factors of PHC in this area. Familial history of liver carcinoma, alcohol ingestion and smoking might also be involved in liver carcinogenesis; Antiviral therapy could reduce the HBV DNA level and PHC morbility in HBV and HCV infected patients. Dangerous age might be in 40～60 years in Hepatitis B patients, particularly in HBsAg, anti-HBe and anti-HBc co-positive patients. Therefore regularly examine might benefit to earlier diagnosis. The specificity and sensitivity of AFP in diagnosis of PHC should be explored.