Screening Colorectal Laterally Spreading Tumor Associated Proteins And Exploring The Roles Of Galectin-1 On Colorectal Carcinoma Cell Phenotypes

Background and objectivesColorectal cancer(CRC) is the third most common malignant tumor in the world,and its mortality is adversely related to the pathological stages,which cauces many interests focusing on the studies of CRC invasion and metastasis.Colorectal laterally spreading tumor(CLST),a new conceptual colorectal tumor,possibly brings some indications to the studies of CRC metastasis for its specific biological behaviors. CLST,often including adenoma and intramucosal carcinoma pathologically,rarely invases deeply but always laterally spreads along the colorectal mucosa morphologically,which is much different to the common CRCs,invasing easily. So CLST natively becomes the adverse lesion pattern in studying on adhesion,invasion and metastasis of CRC possibly,and we speculate that studies on CLST possibly explores the laterally spreading molecular mechanism of CLST and on the other hand potentially indicates something about the invasion and metastasis of CRC.In our previous studies,a CLST cell line LST-R1 with relatively lower invasion ability compared with two CRC cell lines,SW480 and LoVo cell lines,had been successfully established ,and cDNA micoarray had employed to screen its differently expressed genes comparing to SW480 and LoVo cell lines,and several differently expressed genes including ARF1 and TM4SF9 were involved with CRC cell adhesion,motility and metastasis.So exploring invasion and metastasis of CRC from the studies on CLST is promising.Because of the nonline relationship...