Changes Of The Functions Of Immunoregulatory Network In Patients With Epidemic Hemorrhagic Fever(EHF) And Their Significace In The Pathogenesis Of EHF

Epidemic hemorrhatic fever (EHF) is a severe infectious disease with high mortality in china. The pathogenesis of the disease remains unclear; however. the absence of clear evidence for virus cytopathology in fatal cases of EHF and the coincidence of the humoral immune response with disease onset have led to speculation regarding an immunopathologic basis for this disease. Accumulated data demonstrate that there are some obvious disturbances of host immune functions during the course of EHF. Little is known, however, about the relation between these immunological abnormalities and the functions of host immunoregulatory network in EHF. The present study was undertaken to investigate the functions and number of regulatory T lymphocytes as well as several immunoregulatory mediators in patients with EHF, in an attempt to understand immunoregulation in EHF.The function of spontaneous T suppressor cells (STs) and T lymphocyte subsets in patients with EHF were compared. It was found that in the early stages of the disease activity of STs was markedly lower than that of the...