| Objective:The methods and principles based on the clinical epidemiology, through the cross-sectional study and review of clinical research on 200 cases of chronic glomerulonephritis in Early lesions of CKD TCM research, explore the TCM Hou features of the distribution and composition in chronic nephritis; by studying the relevance of TCM Hou chronic glomerulonephritis and clinical biochemical indicators of immunity, in order to provide objective evidence of clinical dialectic; by using factor analysis on the distribution of TCM to analyze and summarize, the objective Reproduction of the nature of chronic nephritis syndrome.Methods:(1) sample size:In.accordance with the general rules of multivariate analysis, the sample size is set to 5-10 times the number of all variables, select the 200 cases of chronic glomerulonephritis patients. (2) "Clinical Case Investigation Form " development: According to the reference to the discipline of expertise developed by the Ministry of Health issued the "Guidelines for clinical research drug medicine"and-traditional Chinese medicine syndromes in terms of clinical diagnosis and treatment part of the development. (3) statistical methods:frequency count data to the table, percentage or description of constituent ratio; differences were analyzed by T test, chi-square test, ANOVA, non-parametric test and other methods; using factor analysis method to extract dominant chronic glomerular Nephritis, the common factor of four diagnostic variables, according to its expertise in analysis and interpretation.Results:(1) The survey has a complete report of renal biopsy in patients with IgA nephropathy the most common, accounting for 54.2% overall, far higher than other pathologic types. (2) frequency of 54 top 10 symptoms are:less gas fatigue> red yellow urine> I suffer> mouth stick> upset irritability> stool viscosity> aversion to cold> lower back pain (ease off)> Easy to sigh> hot flushes and night sweats. (3) The order of the incidence of deficiency are:qi> kidney> spleen> Yang> Yin>Yin deficiency of liver and kidney> Yin moving air; The order of the the incidence of Biaoshi Syndrome are:damp> blood stasis syndrome> liver qi Yu> wet> stagnation of the fire> toxin> phlegm> outside air. (4) The combination syndrome:the Damp-heat+Blood stasis group was more than simply Damp-heat or simply Blood-stasis group; Damp-heat of spleen-kidney deficiency of yang and liver fire were significantly higher than that of the other two groups. (5) Factor analysis of 13 common factors obtained, of which the highest occurrence rate of 10 factors, which include the syndrome of damp-heat and Blood-stasis; Simple factor in the deficiency occurs in the highest rate of factor 8 which mainly lack of qi.Conclusion:(1) the highest incidence is the deficiency of qi in chronic nephritis, while the Damp-heat and Blood-stasis in Biaoshi Syndrome are the mos t common, suggest ing that Damp-heat and Blood-stasis is an important pathogenesis of chronic nephritis, and both may synergistically increase the consumption of healthy qi and block of qi-flow. (2) factor analysis, although not a substitute for traditional TCM, factor analysis, but can be more satisfactory separation of the syndrome successfully by independent groups, especially the top three in both the syndrome include the Blood-stasis and Qi-deficiency, which also verifies t-he main conclusion of the study in the second part of this study. |
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