The Tune Lung Treatment Of Children With Tourette Medical Case Data Mining Research And Traditional Chinese Medicine Research, The Effects On Immune Function

4"调肺"治疗儿童多发性抽动症医案数据挖掘研究及中药复方对小鼠免疫功能影响的研究ABSTRACTObjective By analyzing the Tourette's syndrome cases based on data mining,explore the basic cause and mechanism of Tourette's syndrome withtreatment by regulating lung. And try to discuss the theoreticalsignificance of TS treatment by regulating lung. Meanwhile, study theeffect and explore the possible mechanism of "Regulating lungs'composite prescription on immunity effects in immunodepressed mice withTS.Methods 1. The study of Tourette's syndrome cases with treatment of regulatingthe lung based on date mining (1)Collected 110 cases of patients according to diagnosis andclassification standards Tourette's syndrome. (2)Collected and recorded clinical information according to medicalrecord. (3)Input information and established a database of Tourette'ssyndrome. Data preprocessing, including data standardization andquantification for data indexing. (4)Multiple post-entry verifications.10% of randomly selected caseswere checked to ensure the quality of entry. (5)Analyzed the Tourette's case with "CPDBS" and "CPIAS" 2. Research of the effect of "Tiaofei" composite prescription onimmunity effects in immunodepressed mice The immunodepressed mice models were induced by intraperitonealinjection of cyclophosphamide with 50mg·kg-1. Mice were administratedwith "Tiaofei" composite prescription 3,6,12 g·kg-1 for 7 consecutivedays. The phagocytic activity of monocytes, the delayedhypersensitivity reaction and the haemolysin antibody formation in micewere observed by means of carbon particle clearance, ear swelling andhaemolysin antibodies.Results 1. The study of Tourette's syndrome cases with treatment ofregulating the lung based on data mining (1)The study of Tourette's syndrome cases with "CPDBS"①General information:Tourette's syndrome Incidence rate of boyis higher than girl, the ratio is 5.1:1. Majority in age of 6-15 years old, the incidence rate significantly decreased after age of 15.②Common clinical symptoms of Tourette's syndrome include:redness of tongue, wiry and slippery pulse, greasy tongue, movement tics, vocal tic, redness of pharynx, insomnia, etc.③The causes of Tourette's syndrome included in this research: endogenous wind, heat-phlegm, internal injury caused by excess of emotions, surgical trauma, dyspepsia. But the main cause is endogenous factor which affecting health.④Tourette's syndrome mainly damages liver, counted for 99.09%; heart, counted for 13.64%; spleen, counted for 4.55%; lung, counted for 13.64%.⑤The mechanisms of Tourette's syndrome include:endogenous liver wind, counted for 81.82%; pyrophlegmatic mania,13.64%; splenic asthenia and hepatic accentuation,4.55%; obstruction of collateral caused by wind-phlegm,0.91%.⑥The cases of Tourette's syndrome involved three complex symptoms:endogenous liver wind,81.82%; pyrophlegmatic mania,13.64%; splenic asthenia and hepatic accentuation,4.55%.⑦The treatment of Tourette's syndrome in this research includes calming the liver to stop the wind, expelling wind and dissipating phlegm mainly(counted for 81.82%), easing mental anxiety, eliminating phlegm by cooling, stopping endogenous wind and washing away the phlegm, eliminating phlegm by cooling coordinating. After the complete classification of Statistics, the treatment mainly include calming wind and eliminating phlegm, counted for 89.51%.⑧The most common herbs of Tourette's syndrome prescription include in this reach:siberian cocklebur fruit, lycopodii herba, jujube seed, Chinese quince, prepared RHIZOMA PINELLIZE, biond magnolia flower, figwort root, isatis root, gambir plant.(2)The study of Tourette's syndrome cases with "CPIAS"①Herbs used in the Tourette's syndrome prescriptions include: jujube seed, Chinese quince, lycopodii herba, prepared RHIZOMA PINELLIZE, biond magnolia flower, black snake, gambir plant, paeoniae alba, nux prinsepiae, cicada slough, prepared RADIX GLYCYRRHIZAE, tall gastrodia tuber, etc.②The property of the herbs of Tourette's syndrome prescriptions mainly is mild, warm and cool.③The flavor of the herbs of Tourette's syndrome prescriptions mainly is sweet, bitter and pungent.④Meridian distribution of herbs show up that the maximum distribution percentage is the liver system, followed by the lung system, spleen system, heart system, kidney system, and else.⑤The effectiveness of Tourette's syndrome prescription in this research mainly include:eliminating wind, calming the nerves, heat-clearing, activating collaterals, calming the liver, eliminating sore poison, stopping endogenous wind, improving acuity of vision, eliminating stagnation, relaxing the tendons, which are among the top 10. After screening, the effectiveness of the top 10 in order were heat-clearing, eliminating wind, calming the liver, activating the tendons, eliminating stagnation, eliminating phlegm, stopping endogenous wind, relaxxing the tendons, dehygrosis, purging pathogenic fire.⑥Syndrome elements of Tourette's syndrome prescriptions involved in this research mainly include:pathogenic wind, anxiousness, pathogenic heat, collaterals and subcollateral s blockage, hepatic accentuation, sore poison, pyretic toxicity, muscular contracture, eye, wind symptom, which are among the top 10. After screening effectiveness of the top 10 in order were pathogenic heat, pathogenic wind, hepatic accentuation, collaterals and subcollateral s blockage, stagnation, phlegm, wind symptom, muscular contracture, dampness, distinguish fire.⑦These are ten kinds of complex symptom of Tourette's syndrome prescriptions in this research by order:endogenous liver wind, wind and dampness heated, convulsion caused by heat-phlegm, external cold and internal heat, endogenous wind-evil caused by excessive heat, blockage caused by humid heat, veins and arteries invasion by wind, disturbance caused by phlegm-heat attacking, humid heat caused by stomach intestine blockage, fire-syndrome resulting from wind-heat.⑧Signs and symptoms in this research are focused on movement tic, creasing nose, shrugging shoulders, vocal tic, redness of tongue, yellow fur, wiry and slippery pulse, restless and angry, sleep week, redness of pharynx, which were the the top 10. Redness of pharynx is more significant in the treatment of Tourette's syndrome.2. Research of the effect of "Tiaofei" composite prescription on immunity effects in immunodepressed mice.6 and 12 g·kg-1 dose of "Tiaofei" composite prescription could improve clearance index and phagocytic index in immune function of carbon of mice, decrease ear swelling induced by cyclophosphamide.12 g·kg-1 dose of "Tiaofei" composite prescription could increase content of haemolysin antibody induced by cyclophosphamide.Conclusion1. Through s i gns and symptoms, etiology, disease bits, pa thogenes i s, therapy and prescription medication of medical records, objectively and detailedly analyze the summary of the basic etiology and pathogenesis of the disease. Causes included:affected by evil qi,emotions injuries, dietary factors, trauma factors, genetic, and congenital deficiency. Main problem is located in the Liver, but related with lung, spleen, heart and kidney. Wind, fire, phlegm were the main cause in this disease, and also are pathological products. They also are important factors course of this disease, which worsening of the disease.2. Regulating both inside and outside of the liver and lung are important in this treatment process. In this study, "expelling wind" "harmonizing liver", "removing heat " are the core treatment of the regulating lung therapy. In addition to reflect application of prescription,medication, taste, tropism and effect, also concentrate to the combined effects with all parties of expelling wind, remove heat, harmonizing liver, removing sputum and calm the nerves. In the clinical process, concentrate on the changes in children with nasopharyngeal impact of this disease.3. According TCM, lung and liver have a close link on the physiological and pathological part. Main problem of Tourette's syndrome is in liver, regulating lung also play a therapeutic role. Evil qi turn from Lung to liver is very important factor of this disease. Therefore, regulating lung, has positive effect for Tourette's syndrome. Sputum is also an important pathogenic factor of threatening Tourette Syndrome. Through the "regulating lung" can improve the body's abnormal fluid metabolism, while reducing endogenous sputum evil, which are conducive to the treatment of Tourette's syndrome.4. In treating Tourette's syndrome, the regulating lung composite prescription can enhance non-specific immunity, cellular immunity, humoral immunity, largely reduce streptococcus, viruses and other pathogenic microorganisms infection. Meanwhile, it can play a role in correcting functional status of the disorder with Tourette Syndrome cytokines. It also can induce different cytokine to achieve the homeostasis of physiological. Thus it can stabilize neuro- endocrine -immune network and or reduce the tic symptoms.5. "Zhengqi" can be regarded as immunity in modern medicine. It is decisive factor in the development of disease. The generation, transmission and distribution, whole operation of "zhengqi' are closely linked with lung. Therefore, the "regulating lung" treatment of Tourette's syndrome has some similar meaning with immunomodulatory therapy.6.This study used clinical factors of medical records as starting point, by means of data mining techniques, preliminarily explore of etiology and pathogenesis with regulating lung as clinical treatment point. And verify the feasibility of data mining methods in the study about medical records of Traditional Chinese Medicine.