The Efficacy Of Shuang-Shen-Yin Regimen On The Immunoresponse And Clinical Well-beings Of Cancer Patients Who Are Undergoing Radiotherapy In Malaysia

Objective: Cancer is a major concern worldwide. There are about11million newcases of cancer annually, thus cancer treatment has become the focal point of theglobal medical community. In this research, the combination of modern andtraditional Chinese medicine was used to study and analyze cancer development,treatment, and prevention in Malaysia. For cancer treatment in recent years, the goalof medical profession is to reduce the clinical symptoms, improve quality of life, andprolong the lifespan of cancer patients.This study has shown that the efficacy oftraditional Chinese medicine has an advantage in reducing clinical symptoms,improving quality of life, reducing the side effects of chemotherapy, and increasingthe survival rate of cancer patients.The main purpose of this study is to evaluate andcompare the efficacy of Shuang-Shen-Yin of traditional Chinese medicine to radiationtherapy of modern medicine base on the differentiation of the clinical symptoms, theimmunity and the quality of life of cancer patients. Method: In this research bothmodern and traditional Chinese medicine were used to study the historical evolution,pathogenesis, treatment, and prevention of cancer patients in Malaysia. Investigate theMalaysia Chinese medical treatment of cancer research and summarized the currentstatus. Cancer patients were grouped and category into different gender, race, age, andtheir disease sites and etiology with figure and table analysis. This study has shownthat the invigorating Qi and nourishing Yin of Shuang-Shen-Yin regimen is superioradvantage to the process of radiotherapy; especially in improving the quality of lifeand efficacy of immunity of cancer patients. Clinical studies were done byrandomized single-blind trial with a total of80test subjects, only60test subjectscompleted all the processes.21of them were male and39female.They were testedrandomly and underwent single-blind experiment,32of them in experimental group,and28in control group. The average age of the test subjects was60. and the medianage was57.5.The average course of therapy with prescription invigorating Qi andnourishing Yin of Shuang-Shen-Yiin regimen was11weeks. In radiation therapy, theaverage radiation dose was5440cGy, and the average treatment-cycle was6.94 weeks. The average treatment-cycle of chemotherapy was4weeks. Results: Base onthe principles of traditional Tibetan medicine, traditional Chinese medicine is closelyrelated to study of modern immunology in particular to the rational application oftraditional Chinese medicine in cancer patients. This study has shown that traditionalChinese medicine has attenuated toxification and modulated synergistic effect,improves blood circulation, speeds up blood flow,and reduces oxygen consumptionof tumor cells. It enhances DNA damage of tumor cells induced by radiation damage,inhibits DNA repair of injured tumor cells. and helps to reduce tumorglutathione.Furthermore, it continues to kill the remaining radiation resistant tumorcells, and enhances the immune function of cancer patients thus improving theirquality of life. The different drug classification of traditional Chinese medicine aredetoxification model, strengthens the spleen "Qi", promoting blood circulation toremove stasis drugs, and softening the hard to dissolve nodules drugs. These differentregimens prove to be beneficial in the treatment and prevention of multi-target cancer.There is a significant difference in the count of lymphocyte (p=0.002) and the countof B cell (p=0.005) for the before and after treatments of the experimental group. Inour clinical studies, when using Shuang-Shen-Yin to assess patients for radiotherapy,a conclusion was reached:1.Comparing before and after treatments, there is asignificant change in the Lymphocyte count (p=0.002), and B cell count (p=0.005)of the experimental group in the immune function assessment. The p-value of NK cellcount (p=0.098) is in the range of0.05-0.10in experimental group which shownborderline significant difference in the evaluation of immune modulation.2. Based onthe study of EORTC QLQ-C30questionnaire for the quality of life assessment, theexperimental group was better than the control group significantly (p=0.046) inevaluating the quality of life. The items in EORTC QLQ-30included emotionalfunctioning(p=0.050),cognitive functioning(p=0.017),social functions(p=0.001),fatigue(p=0.005),nausea&vomiting(p=0.006),insomnia(p=0.031),anorexia(p=0.003),economic functions(p=0.021),and the overall lifeassessment/quality of life (p=0.016)。The results of the assessment have shown thattreatment with "Shuang-Shen-Yin" was improved significantly.3.There is a positivecorrelation in immune function indicators, quality of life, and the outcome of "YinDeficiency" syndromes in cancer patients of radiotherapy. Conclusion: Thoughmodern medicine and traditional Chinese medicine are based on two different models,medically there is no great difference in their philosophy. Traditional Chinesemedicine has a long history in Malaysia. It has significant development, and achievedgreat progress in cancer treatment in Malaysia. After studying the practice of"Shuang-Shen-Yin" inside and outside of Malaysia, traditional Chinese medicine hasshown to be an "immuno-potentiator" in cancer patients treated with radiotherapy. It increases the production of lymphocytes, and B-cells in cancer patients consequentlyimproving their emotional functioning, cognitive functioning, and social functioning.It also reduces fatigue, nausea, vomiting, insomnia, loss of appetite, and financialdifficulties of cancer patients thus improving the overall quality of life. With thepositive influence of integrating modern medicine in traditional Chinese medicine,and using the principles of modern medicine to understand traditional Chinesemedicine can help to promote, modernize, provide positive guidance, and leadtraditional Chinese medicine to a greater significance.