Patients With Coronary Heart Disease C-reactive Protein, Apolipoprotein Ai Gene And Apolipoprotein E Gene And Glycoprotein Iii A Gene Polymorphism

Coronary artery disease (CAD), which frequently becomes manifest as myocardial infarction (MI), continues to exact an enormous toll in the world. Despite progress in its prevention, detection and treatment, it continues to be the leading cause of death. Several risk factors for coronary heart disease have been well documented, including hyperlipidemia, hypertension, smoking, diabetes, a positively family history, obesity and inactivity. However, these factors explain only part of attributable cardiovascular disease. It is clear that other and unknown factors are involved. A growing body of evidence supports the concept that local and systemic inflammation play a role in the initiation and progression of 7 atherosclerosis and its complications. C-reactive protein (CRP) is an acute-phase reactant marker for underlying systemic inflammation. CRP bas been reported to be elevated in patients with acute ischernia and MI. The objective of the present study was to test whether CRP correlates with CAD or ACS and whether CRP can also be a risk factor of ACS. CAD is a complex trait in which inherited and environmental risk factors interact to drive the disease process. The fact that classical cardiovascular risk factors are not present in all patients suffering from early coronary disease and that reduction in morbidity and mortality derived from the treatment of these factors is about 30% prompted several groups to explore other factors which could be involved in the pathogenesis of the atherosclerosis and thrombosis process. Recent research has been directed towards the study of new factors implicated in the development of the disease, such as procoagulant factors, homocystenemia and genetic polymorphisms. Genetic studies have identified polymorphisms and mutations in the apolipoprotein (Apo) Al gene, Apo E gene, glycoprotein lila gene and other genes associated with CAD. Our aims were to define the association between CAD in patients studied by coronary angiography that of Uygur and Han nationalities in Urumqi of Xinjiang Uygur Autonomous Region of Peoples Republic of China and polymorphisms at the Apo AT gene, Apo E gene and glycoprotein lila gene respectively. We also analyzed the associations between these polymorphisms and several biochemical parameters. 8 Section 1. C-reactive protein as a risk factor for acute coronary syndrome Objective We assessed the levels of CRP in patients with acute coronary syndrome (ACS) [including unstable angina pectoris (UAP), acute myocardial infarction (AMI) and sudden cardiac death (SCD)j compared with Non-ACS [including stable angina pectoris (SAP), old myocardial infarction (OMI) and healthy volunteers] and sought to test whether CRP are associated with clinical acute coronary syndrome. Methods Ultrasensitive immunoassay (rate nephelometry with the Beckman Array multitest immunoassay system) was used to measure CRP levels in 91 patients with ACS (20 UAP, 71 AMI including 2 SCD) and Non-ACS (34 SAP, 25 patients with healing phase of AMI , 41 OMI and 94 control healthy subjects). Results CRP levels were higher in ACS group (18.50?3.98 mg/L [SE 2.51, n=9 1]) compared with Non-ACS group (3.89 ?.14 mg/L [SE 0.51, n=194])(P<0.0l). Using...