Bushenhuoxue Mixture Experimental Study Of The Cavernous Nerve Of Rats With Dm Ed Sinusoids Role Mechanism

Objetives: To investigate the mechanism of the formula of tonifying the kidney and circulating blood on cavernosal nerve and sinus.Methods: Diabetes was established by the administration of streptozotocin (63mg/kg) intraperitoneally. We selected diabetes erectile dysfunction rats after 8 weeks by apomorphine. The rats were randomly divided into 5 groups: normal control group, model group, the formula of tonifying the kidney and circulating blood(high dosage group, low dosage group), gliclazide with Anxiong group. 4 weeks later, We observe the effect on the blood glucose, hemoglobinAic. insulin, blood rheologic index, corpus cavernosal nerve(electrophysiology, myelin sheaths,nNOS) and sinus (VEGF, eNOSN basement membrane).Results: 1, The formula of tonifying the kidney and circulating blood can lower blood glucose, hemoglobin A1C, improve the function of islets beta-cells and blood rheologic index. 2, The formula of tonifying the kidney and circulating blood can shorten rats cavernosal nerve-cavernosal smooth muscle reflection latent period, lower myopotential, increase nNOS protein expression, enhance remyelination. 3, The formula of tonifying the kidney and circulating blood can increase the volume of cavernous sinus and synthese of endothelial cell eNOS protein, lowering the expression of VEGF protein, inhibiting the proliferation of collagen, lower the thickness of basement membrane.Conclusions: The formula of tonifying the kidney and circulating blood can better the function of diabetes erectile dysfunction rats. The mechanism maybe correlate with it correcting metabolic, cavernous sinus and nerves disorder.