Chinese Medicine Site Compound Dgh Stz-induced Diabetic Rats Blood-retinal Barrier And Visual Function Effects Of Experimental Research

PURPOSE: To observe retinal vessel leakage and visual function damage of Streptozotocin (STZ) induced diabetic rat, and effect of traditional Chinese medicine on the retinal vessel leakage and visual function damage of Streptozotocin (STZ) induced diabetic rat.METHODS: We reproduced diabetic animal model by peritoneal injectionintra of STZ, in the six months after the blood glucose rised, we used Evans blue to trace the leakage of blood-retina barrier and evaluated the visual function by recorded mfERG. After blood glucose rised three month, we treated the Chinese medicine group diabetic rat with DGH capsule and treated the control group with Calcium dobesilate. After three month treated by medicine we evalued the leakage of blood-retina barrier and the visual function.RESULTS: The damage of BRB and visual function occurented at two week after the blood glucose rised, and the diabetic rat model's BRB and visual function damage got worse as the hyperglycaemia keep on. But after the Chinese medicine treated three month, the rat's retina vessel leakage was reduced and the Chinese medicine can protected visual function in the hyperglycaemia by recover the PI wave's amplitude and the protracted peak latency.CONCUSION: The STZ diabetic rat occurrence BRB break down and visual function damage in early phase and get worse as the hyperglycaemia keep on. The Chinese medicine DGH capsule can prevent the vessel leakage by damage of BRB, and DGH capsule can protect the visual function of the STZ diabetic rat.