Glutamine And Growth Hormone To Reduce Its Molecular Biological Mechanism Of Chemotherapy And Parenteral Nutrition In Intestinal Barrier Damage

Glutamine could support the intestinal mucosa and barrier function; rHGH was able to improve the general nutritional status both in animal and human, but its effect on bowel barrier function is unclear, especially when combined with glutamine. Aim: to investigate the effect of glutamine and rHGH on attenuating the bowel barrier function deterioration of rats receiving chemotherapy and parenteral nutrition. Methods: After central catheterization, 40 Wistar rats were randomized into 4 groups. Chow group was given standard chow food. STD group feed with standard parenteral nutrition; Gln group receive standard parenteral nutrition enriched with glutamine dipeptides ( 3% , equivalent to 2 % glutamine). Gln + rHGH group receive standard parenteral nutrition enriched with glutamine dipeptides and rHGH (4.8 mg/kg/d). The parenteral nutrients infusions in the three groups were isocaloric and isonitrogenous. Rats in the 4 groups were given 5-Fu chemotherapy intraperitonealy and maintained with their respective diets for eight days and then harvested. The body weight, ilium wet weight, jejunal mucosal morphology, bacterial translocation of MLNs and intestinal permeability...