Chinese Han Population With Essential Hypertension And Lpl, Add1, At1, Vapr1a Gene Linkage And Association Study

Background: Essential hypertension (EH) is a common cardiovascular disease, and a major risk factor for coronary heart disease (CHD), stroke, cardiac disfunction and renal diseases. Blood pressure phenotype is considered an important index as diagnosis of hypertension, and can be measured conveniently. Not only can numerous physiological pathways regulate BP by constituting a close network within the body, but also a variety of tissue organs, eg, the kidneys, brain, heart, adrenal glands, and blood vessels, are involved in individual pathways. Lipoprotein lipase is a rate-limiting enzyme responsible for the metabolism of lipoprotein. Some flanking microsatellite markers of LPL gene were found linkage with hypertension or BP phenotype in Taiwanese populations in 1996 and 2000. Subsequently, several significant linkage and association findings were also detected in Chinese southern population and southern Han Chinese origin and were living in the Hong Kong. But the relationship between the LPL gene and hypertension was controversial among Caucasian populations. Since the majority of Taiwanese have consanguinity with Chinese Han people, the present study was to discuss whether the polymorphisms of the LPL, AT1, ADD1 and VAPR1A genes and some phenotypes, such as SBP, DBP, TG, TC, HDL-C and LDL-C, were associated with the genesis of hypertension in homogeneous Chinese population.Methods: A total of 148 hypertensive families came from Beijing suburb, Shanxi province and Jiangsu province. All subjects are the Han ethnicity. To be eligible for our study, a proband in each nuclear hypertensive family had to meet the following criteria: Age greater than 15 years; Either of two parents with hypertension; Two or more siblings with hypertension; No clinical and biochemical indexes of secondary hypertension; detail clinical differentiation including clinical laboratory tests on certain patients implemented to exclude patients with other known diseases such as acute or chronic glomerulonephritis and pyeloniphritis, Cushing syndrome or pheochromocytoma etc; Without the use of cortisone-based medications or estroprogestinic hormones (by women); and Resting-sitting SBP≥140 mmHg and/or...