The Clinical And The Experimental Research Of Metabolic Syndrome Treated By The Method Of Eliminating The Turbidity In Blood And Warming Yang

Objective: Completely expounded the theoretical system of blood turbidity, Through the observation of clinical and experimental research, this study is primarily to discuss the mechanism of treating Metabolic syndrome by the method of eliminating the turbidity in blood and warming yang, provide a new way for treating MS. Methods: In clinical observation, 65 cases were divided into two groups, they are group of taking orally Huazhuoxingxue Tang and Epimedium (33 cases), group of taking orally Rosiglitazone (32 cases). The treatment course of each group is eight weeks. We observed the change of Clinical symptom , TCM syndrome, waist, waist-hip ratio, weight and body mass index, blood fats, blood sugar, blood pressure, fasting insulin and insulin resistance index of each group. In experimental research, 32 male Sprague Dawley rats were randomly divided into four groups: Chinese medicine-treated group, western medicine-treated group, model group and control group. The control group were feed basic diet, and the rest groups were established to be insulin resistance models with feeding high-fat-salt diet in 8 weeks. Then the Chinese medicine-treated group were treated with HuazhuoxingxueTang and Epimedium, the western medicine-treated group with Rosiglitazone, the model group and the control group with physiological saline. The treatment course of each group is four weeks. We observed the change of body weight, blood fats, blood sugar and insulin resistance index, leptin, TNF-αand internal fat level of each group. Results: The treatment of taking orally Huazhuoxingxue Tang and Epimedium can more effectively improve clinical symptom, reduce the blood pressure , the blood cholesterol, the waist, the waist-hip ratio, the weight and body mass index level than taking orally Rosiglitazone, and in the other hand taking orally Rosiglitazone more effectively than taking orally Huazhuoxingxue Tang and Epimedium in reducing triglyceride level. The experimental research tell us that both of Huazhuoxingxue Tang and Epimedium and Rosiglitazone can effectively improve insulin resistance, reduce blood fats, blood sugar, TNF-αand leptin level of MS model rats, taking orally Huazhuoxingxue Tang and Epimedium can more effectively reduce body weight and internal fats than Rosiglitazone. Conclusion: The syndrome of blood turbidity and deficiency of Yang is the basic TCM pathogenesis of MS, Huazhuoxingxue Tang and Epimedium has improving effect on glucose and lipid metabolism, insulin resistance , central obesity, and abnormalities of blood pressure; and its mechanisms may be: reducing body weight and internal fats, regulating above adipocytokines, controlling inflammational state in the body and improving insulin resistance.