| Although the development of prostatic cancer is multi-factorial, accumulating evidences suggest that chronic prostatitis plays an important role in cancer development. Immune function disorder is considered as the common feature of prostatic cancer/carcinoma, as well as prosititis. My initial research confirmed that Traditional Chinese Medicine(TCM) is effective in treating advanced stage prostate cancer by regulating the immune function of patients and in curing prostatitis. So we assume that by analyzing the metastasis mark and immune-associated indexes of prostatic cancer patients, it is likely to get the curative regularity after TCM intervention, which may unveil the internal connections between chronic prostatitis and prostatic carcinoma, and may render a service to TCM preventive effect.Object iveTo investigate the influence of dialectic TCM therapy on treating prostatitis, and to make preliminary research on prevention of prostatic carcinoma by observing the immunological changes of Category III prostatitis and their relationship with prostatic specific antigen (PSA), and by evaluating the effectiveness of damp elimination and stasis removing on these immunological indexes.Materials and MethodsThere were 52 cases of patients with Category III prostatitis which were from Urology Clinic of Guangdong Provincial Chinese medicine Hospital. The subjects were randomized to treatment group and control group. Patients in treatment group were treated with TCM therapy to eliminating dampness and removing blood stasis(Basic recipe plus or minus:Toosendan 10g Yuanhu 10g Wulingzhi 10g Puhuang 10g HuangbailOg Cangshu 10g Niuxi 15g Coix bidentata 20g). While subjects in control group were treated with antibiotics Norfloxacin. The course of treatment was two months. During the treatment course, a series of immune parameters/immunolization indicators were measured and observed, including peripheral blood T lymphocyte subsets (CD3 +T, CD4+ T and CD8+ T), serum PSA, prostatic EPS:TGF-β1. Statistical analysis of the data were made to compare the influence of interventions on immune parameters/immunolization indicators.ResultsBefore treatment, the symptom score and quality of life score of two groups did not have statistical difference between (P>0.05). After 2 month treatment, in general, the most symptoms alleviated. Each index of the treatment group were significantly different compared with pre-treat level (P<0.0001). All the indicators of control group other than that of the quality of life have statistical significance (P<0.05). The quality of life had no statistically significant compared with pre-treat (P>0.05). After treatment, some differences between the average number of the two groups, of which the pain symptoms, quality of life, the overall total score difference was significant (P<0.0001), and the urinary symptoms between the two groups was no significant difference (P>0.05), total symptoms between the two groups was statistically significant (P<0.05). The average deviation between the two groups in urinary symptoms and quality of life have statistically significant (P<0.05), and the significant difference (P<0.0001) in the pain score, symptom score, overall score between two groups.Before treatment, the level of total prostatic specific antigen (T-PSA) of two groups did not have significant difference. After 1 month treatment, the level of PSA of control group declined significantly compared with pre-treat level (P<0.05); but without significance; the T-PSA level of treatment group declined without significance; and there was no marked difference between the two groups. At the end of the second treatment course, T-PSA level of both groups declined with marked significance (p<0.05); and there is no significant difference between the two groups. No statistical meaning existed in F/T before and after treatment.Before treatment, the CD4+/CD8+ level of two groups were not significantly different. At the end of the 1st month, CD4+/CD8+ level of the treatment group increased compared with pretherapy, with no significance (P>0.05); CD4+/CD8 +level of control group declined with no statistical significance (P>0.05); and there was no significant difference between the two groups. The 2nd month showed that the CD4+/CD8+ level of treatment group had risen, compared with pretherapy, which was significant (P<0.05). CD4+/CD8+ level of control group increased, compared with that pre-therapy condition but without significance (P>0.05); and no significant difference between the two groups (P>0.05).Before treatment, CD3+ levels of two groups had no significant difference. In the 1st month, CD3+ level of the treatment group increased, but was not significant (P>0.05), the CD3+, level of the control group decreased, but was not statistically significant(P>0.05); there was no significant difference between the two groups. In the 2nd month, it showed that the CD3+ level of treatment group increased compared with pretherapy, and it was significant (P<0.05); CD3+ level of the control group decreased, compared with that pre-therapy, which was not significant (P<0.05); and there was significant difference between groups (P<0.05).Before being treated, the transforming growth factorβ1 (TGF-β1) level of two groups was not significantly different. In the 1st month treatment, TGF-β1 level of the treatment group decreased, yet without significance (P> 0.05); that of control group declined was not statistically significant (P> 0.05); there was no significant difference between the two groups. In the 2nd month, it showed that the TGF-β1 level decreased in treatment group compared with pretherapy, without significance (P<0.05); the level of TGF-β1 of control group slightly increased compared with that pre-therapy conditions, which was not significant (P<0.05); and there was significant difference between the two groups (P<0.001).ConclusionsThe Research supported the point of view that obvious immune disorder exists in CategoryⅢprostatitis patients on some degree. Traditional Chinese medicine's eliminating dampness and removing stasis treatment can regulate the immune function disorder. In regard to the impact of PSA, after 2 months of treatment, there's no significant difference comparing Traditional Chinese Medicine therapy with the norfloxacin therapy. For the influence on cellular immunity, Traditional Chinese medicine can change, to some extent, the the low expression state of CD4+ CD8+ CD3+ and CD4+/CD8+, and regulate transforming growth factor TGF-β1 at the same time. Therefore, the TCM therapy on eliminating dampness and eliminating stasis was confirmed effective on regulating immune functional disorders of CategoryⅢprostatitis and on gearing immune function to normal level.
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