Beijing Han Adiponectin Levels In Patients With Coronary Heart Disease And Coronary Heart Disease Clinical Features And Prognostic Analysis Of The Relationship

BackgroundThe importance of different cardiovascular risk factors varies among different countries and ethnicities, which are also associated with degree of coronary artery severity. Hypoadiponectinemia has been reported to be associated with cardiovascular disease and cardiovascular risk factors, and plasma adiponectin level is different among different ethnicitiesObjectiveTo analyse distribution characteristics of cardiovascular risk factors and clinical characteristics within patients with coronary artery disease in Beijing Han. To explore the relationship between adiponectin level and cardiovascular risk factors, and to investigate the relationship between adiponectin and prognosis of cardiovascular diseases, especially coronary artery disease.Design and methodA total of 503 hospitalized patients undergoing coronary angiography, who were Beijing Han, from July 2007 to May 2009 in Peking Union Medical College Hostipal were included. All patients' clinical data, including classic cardiovascular risk factors, creatinine clearance, left ventricle ejection fraction were recorded after admission and those with cardiovascular disease were followed up till March 17, 2010(1month to 31monthes). The primary end point was the combined occurrence of major adverse cardiovascular cerebral vascular events(MACCE), including cardiovascular death, non-cardiovascular death, targeted vascular revascularization, myocardial infarction, rehospitalization due to unstable angia and heart failure, transient ischemic attack and stroke. And analysis was conducted to identify the relationships among risk factors, coronary artery disease and coronary score. Exploration was made to find the relationship between the plasma adiponectin level and the MACCE and the factors influencing prognosis.Results 1, Among Beijing Han patients with coronary artery disease, male gender[P<0.01, OR 2.648,95%CI (1.494-4.692)],2-DM[P<0.01, OR 2.399,95%CI (1.251-4.602)], smoke[P<0.01, OR 4.441,95%CI (1.356-14.548)] are associated with coronary artery disease.2, Compared with other classic cardiovascular risk factors, coronary artery severity degree is associated with male,2-DM and hypertension by ways of coronary score systems (P＜0.01)3, The patients with coronary artery disease was accompanied with reduced left ventricular ejection fraction[P<0.01,95%CI (0.874-5.829)], reduced renal function[P<0.01,95%CI (5.137-17.594)], and elevated HsCRP level, which were associated with degree of coronary artery severity.4, The risk of MACCE is associated with stenosis of coronary artery[P<0.01,95%CI (3.973-19.401)], left ventricular ejection fraction[P<0.01,95%CI (0.859-2.523)] and the level of HsCRP[P<0.01,95%CI (1.342-6.219)].5, Plasma adiponectin level is associated with classic cardiovascular risk factors. Multiple regression analysis shows adiponectin is associated with risk of MACCE (RR=0.43, P<0.05), which is not influenced by classic cardiovascular risk factors and degree of coronary artery severity.Conclusion1, Among classic cardiovascular risk factors, smoke, male and 2-DM are more closed to coronary artery disease within Beijing Han. Those patients were accompanied with impaired cardiac and renal function and elevated HsCRP level, which were associated with degree of coronary artery severity.2, Adiponectin is associated with classic cardiovascular risk factors, and it is an indepent predictor of prognosis of coronary artery disease.