Identification Of MiRNA-145 Induces Apoptosis In Breast Cancer

Since the discovery of miRNA, microRNAs play pivotal roles in cell proliferation, apoptosis and tumorgenensis, but many of their mRNA targets are yet to be elucidated. According to the research, miRNA targets on their binding site and affects the gene expression level after transcript. Identification of miRNA targets is critical to unravel their corresponding functions in different biological processes. In this study, miR-145 was found to be a significant reduction in breast cancer and to induce apoptosis in cancer cells by targeting the adhesion molecule, discoidin domain receptor 1 (DDR1). Base on the P53 mutant mice animal model, we found that P53 could increase miR-145 expression. Our study suggests that the mir-145 gene is involved in p53-Ddrl axis, which might be a potential candidate in treating breast cancer.