The Preliminary Study On The Relationships Between The Levels Of Endocrine Related Hormones And Metabolic Syndrome In Aged Men

Objective To preliminaryinvestigate the relationships between the levels ofendocrine related hormones[including calcium,25-hydroxy vitamin D(25(OH)D),parathriod homone(PTH), sex hormones andthyroid function parameters] andmetabolic syndrome(MS) and its components in aged men over60years of age.Methods Using cross-sectional study, aged menover60years old wereenrolled,who participated in a routine annual health screening examination atPLA general hospital from May to June in2011and2012. Serum lipids,glucose,calcium,25(OH)D, PTH, sex hormones andthyroid function parameterswere measured along with body height, weight and blood pressure. MS wasdefined according to recommendations generated by the guidline of ChinaMedical Association Diabetes School Grade Meeting (CDS) in2004.Theassociation of the levels of endocrine related hormones with the presence of MSand its components were analyzed.ResultsPart one Correlation of serum calcium,25(OH)D and PTH levels with MS inaged men： The mean values of blood calcium,25(OH) D, PTH were(2.4±0.1)mmol/L、（22.1±9.7）ng/mL and（40.8±16.6）pg/mL respectively. VitaminD deficiency was found in47.3%of aged men in this study. The prevalence of MSwas22%.The PTH levels were significantly higher in the MS and abnormal bloodglucose and HDL-C group than in their control group(P<0.05), whereas therewere no significant differences of25(OH)D and calcium between these groups.The prevalence of MS showed a gradual increase according to the PTHquintiles(P<0.05). When comparing subjects in the highest and lowest quintile of PTH, the former group demonstrated a1.51-fold increase in the odds ratio for MSafter adjusting for25(OH)D levels and other confounding factors. Logisticregression analysis showed that the PTH levels were independent influencefactors for MS in aged men（OR=1.007，95%CI:1.000～1.014，P=0.047）. Thelevels of25(OH)D and calcium were not associated with MS in the regressionmodel.Part two Correlation of serum sex hormone levels with MS in aged men: Agedmen with MS had lower levels of sex hormone binding globulin (SHBG), totaltestosterone (TT),free testosterone (FT) andbioavailable testosterone (BT) thanthose without MS. The levels of SHBG,TT,FTand BT were significantly lower inthe overweight/obesity, abnormal blood glucose and dyslipidemia groups than intheir control groups respectively(P<0.05). Logistic regression analysis showedthat the SHBG levels were independent influence factors for MS in aged men（OR=0.977，95%CI:0.964～0.989，P<0.001）, but the levels of TT, FT and BTwere not associated with MS in the regression model. The prevalence of MSshowed a gradual increase according to the quartile values of SHBG decreasing(P<0.05). When comparing subjects in the lowest and highest quartile of SHBG,the former group demonstrated a2.13-fold increase in the odds ratio for MS afteradjusting for age, smoking,drinking and other sex hormone indices.Part three Correlation of thyroid-stimulating hormone with MS in euthyroidaged men：The thyroid stimulating hormone(TSH) level was significantly higherin the MS and obesity group than in their control group (P<0.05).. The prevalenceof MS and obesity showed a gradual increase according to the TSH tertiles. Whencomparing subjects in the highest and lowest tertile of TSH, the former groupdemonstrated a1.872-fold and1.904-fold increase in the odds ratio for obesityand MS after adjusting for age and HOMA-IR(95%CI:1.051-3.332;95%CI:1.070-3.387; respectively）. Logistic regression analysis showed that the TSHlevels were independent influence factors for MS in aged men（OR=1.324，95%CI：1.042－1.683，P=0.022）. Conclusions1.In aged men, the elevation of PTH levels were found to be a risk factor for theprevalence of MS, but there was no association between25(OH)D and MS.2. In aged men, lower SHBG levels were found to be an independent predictor forthe prevalence of MS, but the lower levels of TT,FT and BT were not associatedwith increased risk of MS, which the mechanism requires further studies.3.High circulating TSH levels, albeit normal, were associated with increased riskfor the metabolic syndrome in aged men.