| Objective:Relying on the National Clinical Research Base Construction Projects, construction of Lung Disease Database, to explore the rule of old the syndrome differentiation of TCM in the treatment of Chronic Bronchitis and medical experience and beijing-tianjin-hebei with syndrome differentiation regularity of jiangsu region difference, provide reference for clinical treatment of Chronic Bronchitis.Methods:With modern name old doctor of TCM treatment of lung disease in clinical work of clinical experience and basis for the data source, according to the diagnosis, filtered into, elimination, entry standards, through the fields, program design, construction of structured database, extract,1274 cases of Chronic Bronchitis medical record. First use Lantern3.1.2 (kongmin light) implicit structure analysis software to build the latent structure model of symptoms, drugs, and then to interpretation implicit class. Use SPSS 19.0 statistical software, high frequency symptoms were selected, drugs for clustering and factor analysis. Use SAS9.1 to high-frequency medicines, medicine medicine, medicine, medicine-the association rules between different fields, such as data mining. Distinguish between visits to hebei and jiangsu region of the medical record, use Lantern3.1.2 (kongmin light) implicit structure analysis software for symptoms, drug latent structure model is established, a comprehensive clustering and implicit interpretation; The mining results analysis, induction and summary, find the potential rule.Results:①Collecting 1274 cases of Chronic Bronchitis medical cases, among which 624 were male, female 400 cases, used aged 50 to 69 years old, high incidence, in the spring and winter cases mills involved 29 provinces, with hebei and jiangsu region is given priority to, its 1,668 cases of confirmed cases.②1274 cases of medical record containing 53 kinds of syndrome types, often witness type phlegm heat accumulate lung (324 times), lung phlegm turbidity resistance certificate (247), cold make lung syndrome (132), article 13603 symptoms, common symptoms of cough (1514) (625), Asthma, cough up phlegm (568). For 84 latent structure model was constructed to get 20 hidden variables,39 class,7 comprehensive clustering model, general symptoms of top 100 R type cluster after get 19 cluster groups. 1274 cases with tongue article 1157 and article 2540 of tongue coating, pulse condition 3007, including different tongue of 27 and 23 species of coating on the tongue and pulse condition 24, common tongue for red tongue (359) (148), pale tongue, reddish tongue (112), the coating is white moss (705), thin moss (570), greasy moss (499), pulse condition is for (677), fine veins (543), string (449) of arteries and veins.The general symptoms of first diagnosis, tongue and pulse condition show variable latent structure model was constructed, and a total of 188 get 35 hidden variables,71 classes,10 comprehensive clustering model.1274 cases of Chronic Bronchitis medical record share 435 kinds of TCM, commonly used drugs licorice root (1257) (1072), bitter almond, pinellia (1009), (866) dried tangerine peel, poria cocos (812), cough antiasthmatic drugs type (3855), mend angry medicine (2991) and qing phlegm heat medicine (2042), taste gansu (11923), (10241), bitter (9312), belongs to the lung (17550), spleen (9733), the stomach (8463) medicinal wen (7472), (4468), lukewarm (3557). In 1481, the famous 1191, unknown common famous small qinglong decoction (105), MaXingShi sweet soup (80), two Chen Shang (60). To build a diagnosis of 147 kinds of drugs latent structure model for 44 hidden variables,88 class,7 comprehensive clustering model. Top 100 flavour drug for association rules mining, and set the minimum support degree is 5%,75% confidence level, to get rid of licorice then we have two lian 9 group, sanlian 50 group, the quadruple 89 group. In 297 cases of two clinical medicine comparisons between medical record after diagnosis, drug and symptoms of duplex 24 groups, two diagnosis to reduce drug have ephedra (64), bitter almond (54), liquorice (52), pinellia (47), Perilla (46), increase of poria cocos (47), atractylodes (44), bitter almond (34), dangshen (33), dried tangerine or orange peel (33). To 83 before a clinical symptoms and the first 96 drugs as variables, latent structure model was constructed to get 50 hidden variables,101 class.346 cases of Chronic Bronchitis of beijing-tianjin-hebei region general symptoms f medical record for the first diagnosis, tongue and pulse condition show variable latent structure model was constructed, and a total of 110 got 17 hidden variables,34 classes, six integrated clustering model.137 drugs of beijing-tianjin-hebei region latent structure model is established to get 27 hidden variables,54class,7comprehensive clustering model. Medicine-disease of beijing-tianjin-hebei region association rules mining, and set the minimum support degree is 5%, the confidence level of 60%, when the statistical drug duplex between 74 group, sanlian group,273 quad 411 groups. For jiangsu region general symptoms of 354 cases of Chronic Bronchitis medical record for the first diagnosis, tongue and pulse condition show variable latent structure model was constructed, and a total of 102 got 13 hidden variables,26 classes,7 comprehensive clustering model. For jiangsu region 129 drugs latent structure model is established to get 30 hidden variables,60 classes,9 comprehensive clustering model. For jiangsu region medicine on disease-the association rules mining, duplex 47 between drag groups, sanlian group,149 quad 132 groups.Conclusion:①Chronic Bronchitis perennial root as "phlegm", the phlegm and eliminating stasis, attaches great importance to the tonic lung, spleen, kidney, especially heavy "the day after tomorrow",Beijing-tianjin-hebei, jiangsu region the physical characteristics of Chronic Bronchitis patients respectively in the dry "virtual" under wet and cold "under" keen on wet, etiology of cold, dry and phlegm dampness respectively (turbidity), phlegm retention, phlegm heat.②Treatment often used bitter almond, pinellia, dried tangerine or orange peel, poria cocos, medicinal, partial f partial temperature, may be, belong to the lung, spleen, kidney meridian;Beijing-tianjin-hebei before hu, dried ginger, cassia twig, commonly used medicinal slants cold, stomach after, jiangsu asarum, cassia twig, white mulberry, commonly used medicinal slants cold, cold, stomach, liver meridian. ③Let an update atractylodes and poria cocos, asarum, fructus schisandrae and pinellia, poria cocos, dangshen, pinellia and dried tangerine or orange peel;Beijing-tianjin-hebei snakegourd fruit and radix pseudostellariae, indigo naturalis, tokay, cordyceps sinensis, jiangsu has a Japanese ardisia and credit, spurge, acid-insoluble ash and dry.④Medicine syndrome (card) associated with ephedra, bitter almond, cassia twig and sputum less;Beijing-tianjin-hebei has cold and pinellia, cassia twig, fructus schisandrae, jiangsu, acid-insoluble ash, cordate houttuynia, salvia miltiorrhiza and cough up phlegm, angelica, rehmannia root, tokay, and coughing, pinellia and outside in the cold drink syndrome, lung phlegm turbidity resistance, lungs and spleen deficiency syndrome, bitter almond lung syndrome, phlegm heat and phlegm turbidity resistance aggregates lung syndrome, cold make lung syndrome.⑤Latent Structure Model can be used to quantify tacit knowledge of traditional Chinese medicine, for the first time extended to drugs, drug level, to quantify the different variables on the same set of data of status and find the points area, time, and the regularity of treating Chronic Bronchitis.⑥This study concluded that in the name of the old law of TCM syndrome differentiation of Chronic Bronchitis has certain reference value to the clinical diagnosis and treatment, the data sources, analysis method, the mining results relatively reliable, objective, can provide a reference for other disease syndrome differentiation regularity of mining. |
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