Standardized Research On Integrated Traditional Chinese Medicine Therapy In The Treatment Of Xeroma

Background:Xeroma is a disease of ocular surface characterized by Symptoms of ocular discomforts and visual dysfunction, which is the result of abnormal tear quantity or quality or fluid dynamics of the tear film. With the problem of human aging, air pollution and the popularization of computer and contact lenses is increasingly serious.Xeroma has a Serious impact on people’s quality of life. For the time being the cause and mechanism of xeroma are not fully known to us. The methods of effective treatments are still not present.Removing the causes and remedy of the primary disease is the key to the treatment of xeroma. Artificial tear substituent is the first-line drug, eternal or temporary blockage of tear duct in mild to moderate dry eye is effective,and Corticosteroids and immunosuppressants is effective for those with moderate to severe inflammatory reaction. There is risk of significant complications with systemic application of sex hormone and tear secretion. We have demonstrated that Runmuling, an oral granule preparation composed of Bidens Bipinnata L, medlar and chrysanthemum and acupuncture separately showed better curative effect in treatment of xeroma,on the basis of looking for safe, reliable and effective traditional treatment methods, we need to further standardize integration of integrated traditional Chinese medicine therapy.Objective:Through standardized research,to summarize the integration and optimization of integrated traditional Chinese medicine therapy in the treatment of xeroma, improve the technical standards of operation procedures of acupuncture, investigate the exact curative effect and security of integrated Traditional Chinese Medicine therapy on xeroma, forming the guide of the clinical diagnosis and therapy standard and which is facilitated application and popularization in West hospitals and primary hospitals.Methods:645patients with xeroma are investigated with A randomized, parallel design, positive drug control, multi-center method, divided into Runmuling treatment group (group A)215cases, integrated Traditional Chinese Medicine therapy group (group B)215cases and tears natural control group (group C)215cases separately, Since the beginning of the treatment, the patients are observed and evaluated every two weeks in terms of symptom score, SIT, BUT, corneal staining and the results were statistically analyzed by superiority test. Results:The efficacy of Integrated traditional Chinese medicine therapy group and Runmuling treatment group is superior to tears natural control group:The efficiency of TCM syndrome curative effect of group A,B,and C is79.88%,84.85%and67.74%separately, Group A and B are superior to group C, the difference is statistically significant,especially efficiency in moderate to severe patients in group B is superior to group C statistically; About "symptom disappearance rate " efficacy, dryness, fear of light symptom disappearance rate in group A and group C is12.35%,69.41%and10.86%,57.01%, there was statistically significant difference between the groups; Symptom disappearance rate of dryness, foreign body sensation, burning sensation and visual fatigue symptoms in group B was21.89%,60.36%,81.66%and53.25%and those in group C was10.86%,43.44%,74.21%and23.53%, there are significant differences between the two groups before and after treatment, group B is superior to group C;there is statistically significant difference among the three groups in the total symptom score after6and8weeks of treatment, group A and B are superior to group C; there was also significant difference in BUT and SIT in group A, B than in group C, the difference was statistically significant;The efficacy of Integrated Traditional Chinese Medicine therapy group is better than that of Runmuling group:The difference of curative effect between two groups was statistically significant, group B is better than group A;there was statistically significant difference in symptom disappearance rate of dryness and visual fatigue between group B and A; the total symptom score after8weeks of treatment in group B is superior to group A, the difference is statistically significant, the total symptom score improvement of dryness and visual fatigue in group B is better than that of group C, the difference was statistically significant;Conclusion:Effect of Runmuling in treatment of xerophthalmia is exact,integrated traditional Chinese medicine therapy that combined of Runmuling and acupuncture is better than that of pure Chinese herbal medicine runmuling.