Based On The Theory Of "deficiency And Stagnation Of Qi", It Explores The Medication Rules And Curative Effect Mechanism Of Traditional Chinese Medicine In The Treatment Of Atherosclerosis

Atherosclerosis is an important pathological basis of ischemic cardio cerebrovascular disease,and it has become a serious disease endangering human health because of lack of effective control drugs.Deficiency in origin and excess in superficiality is the etiology and pathogenesis of atherosclerosis in traditional Chinese Medicine that Involving multiple organs and pathogenic factors.It is caused by improper diet,old age and poor mood at the first time,and then because of the deficiency of internal organs,the metabolism of Qi,blood and body fluid is abnormal,and then form phlegm and blood stasis,even heat and toxin could appear,finally the patients suffer from atherosclerosis.The main clinical symptom of this disease is phlegm and blood stasis,which could be accompanied by Qi deficiency or toxic,heat,wind evil.Therefore,in the treatment of traditional Chinese medicine,many researches mainly focus on promoting blood circulation and resolving phlegm,and treatments have been proven to prevent atherosclerosis and improve clinical symptoms at multiple levelsThe pathogenesis theory of "deficiency Qi retention" was put forward by Academician Wang,it means that deficiency of vital energy will leads to abnormal metabolism of Qi,blood and body fluid,which eventually becomes pathological product stagnation in the body.We can see that the pathogenesis theory of "deficiency Qi retention"can highly accurately summarize the pathological process of some diseases.And we found that the pathological process of atherosclerosis in traditional Chinese medicine is highly consistent with the pathogenesis theory of "deficiency Qi retention",so we can use the pathogenesis theory of "deficiency Qi retention"to guide clinical treatment.At present,there are few clinical studies on intracranial atherosclerosis.But apoplexy is a major disease endangering health,and patients with sICAS have higher incidence rate of stroke and recurrence rate,so the treatment of sICAS is very important for the prevention and treatment of stroke.First we intend to test the efficacy of traditional Chinese medicine in the treatment of atherosclerosis through Meta-analysis,then we are going to explore the usage of traditional Chinese medicine through literature data mining,finally,we will combine the results of previous studies,under the guidance of the pathogenesis theory of "deficiency Qi retention",propose a new Chinese medicine prescription to treat SICAS,and explore its mechanism of action.Study 1:Meta-analysis on Clinical Effect of HTHX Chinese Medicine Combined with Routine Western Medicine for Carotid AtherosclerosisObjective:Systematic evaluation of the clinical efficacy of HTHX Chinese medicine in the treatment of carotid atherosclerosis.Methods:Searched for literature from January 1980 to July 2019 in Chinese National Knowledge Infrastructure(CNKI),Wanfang DataKnowledge Service Platform,VIP Chinese Journal Database(VIP),PubMed,CochraneLibrary.Selected clinical randomized controlled trials,extracted the data from selected literatures,and evaluated quality of literatures by advanced Jadad scoring method.The Meta-analysis was conducted via Review Manager 5.3 software.Results:9 clinical studies were included,including 775 cases totally.The result showed that when compared the HTHX chinese medicine combined with routine western medicine carotid atherosclerosis with that of simple routine western medicine,the effective rate and the reducing IMT,Crouse plaque score,serum total cholesterol,serum triglyceride,serum low density lipoprotein cholesterol and the increasing serum high density lipoprotein cholesterol in the treatment group was superior to that in the control group,the difference being significantConclusion:the HTHX chinese medicine combined with routine western medicine for carotid atherosclerosis can effectively improve clinical symptoms,plaque stability and serum lipid level of patients.So It has the value of further exploring the law of clinical medication.Study 2:Study on the medication rule of Phlegm Blood Stasis Syndrome in atherosclerotic disease based on Data MiningObjective:To explore the clinical medication rule of phlegm and blood stasis syndrome in atherosclerotic diseases.Methods:Searched for literature from January 2000 to December 2019 in Chinese National Knowledge Infrastructure(CNKI),Wanfang DataKnowledge Service Platform,VIP Chinese Journal Database(VIP),Selected the clinical study on TCM treatment of syndrome of phlegm and blood stasis in atherosclerotic disease,extracted data from literature,used Traditional Chinese Medicine Inheritance support system software to analyze the data.Results:TCM treatment of atherosclerotic diseases by traditional Chinese Medicine,(1)The highest frequency of drugs are salvia mil,rhizome of Chuanxiong,pinellia ternata,astragalus membranaceus and poria cocos;(2)The most of the four properties are warm,cold and flat,and most of the five tastes are bitter,pungent and sweet;(3)The most meridian tropism are liver,spleen and heart meridian;(4)The highest frequency of medicine combination are salvia mil and rhizome of Chuanxiong,salvia mil and astragalus membranaceus,rhizome of Chuanxiong and astragalus membranaceus,pinellia ternate and rhizome of Chuanxiong,salvia mil and poria cocos;(5)We got 10 new prescriptions by using the software.Conclusion:Promoting blood circulation and resolving phlegm is the main method to treat the syndrome of phlegm and blood stasis in atherosclerotic disease,but the method of supplementing Qi is also very effective,also the method of regulating qi and detoxification should be taken into account.This conclusion accords with the therapeutic thought of the pathogenesis theory of "deficiency Qi retention".Study3:Clinical study of Yiqi Huatan Tongluo Decoction in the treatment of symptomatic intracranial atherosclerotic stenosis.Objective:To explore the therapeutic effect and mechanism of Yiqi Huatan Tongluo Decoction in the treatment of sICASMethods:By using the method of randomized double blind control,30 patients were divided into control group(15 cases)and experimental group(15cases).The control group was treated with conventional western medicine and placebo of traditional Chinese Medicine for 3 months,the experimental group was treated with routine western medicine plus Yiqi Huatan Tongluo Decoction for 3 months.All patients were tested the safety index,TCM symptom scale,serum mechanism index and nuclear magnetic resonance index before treatment and 3 months after treatment.Results:In this study,30 patients were included,6 patients were dropped,14 patients were included in the experimental group and 10 patients in the control group.Before treatment,there was no significant difference in the baseline of gender,age,disease condition and TCM syndrome score between the two groups.After treatment,the improvement of TCM syndrome score,cerebral perfusion,hs CRP,MMP-9,IL-6,ICAM-1 in the experimental group was better than control group,and the difference was statistically significant.There was no obvious adverse reaction and no obvious abnormality in safety index in both groups.Conclusion:Yiqi Huatan Tongluo Decoction can improve the TCM syndromes and cerebral perfusion of SICAS patients.Yiqi Huatan Tongluo Decoction can inhibit the local inflammatory reaction and the formation of new blood vessels in the plaque by reducing the levels of serum IL-6,hs CRP,MMP-9 and ICAM-1,and play a role in slowing down the progress of atherosclerosis and stabilizing the plaque.