Study On Prescription Regularity Of Qi Stagnation And Blood Stasis Syndrome Based On Data Mining Method

Objective:the syndrome of qi stagnation and blood stasis is the ancient medical records and clinical syndromes in common, it generally exists in various diseases, although since ancient times there is Qi Promoting Blood Circulation and removing blood stasis therapy, but the treatment with drug is complex. Therefore, the use of modern methods of data mining, analysis of prescription on the treatment of syndrome of qi stagnation and blood stasis of ancient medical books and modern patent database, and on medication and prescription regularity of TCM treatment of this syndrome, including herbs, herbal combination, combination, a new combination of core content of preliminary study, retrospectively for clinical guidance syndrome of qi stagnation and blood stasis, and provide valuable reference, to make some contribution to the improvement of qi stagnation and blood stasis type the clinical curative effect.Methods:Screening 31 prescriptions from "Shanghanlun", "Jinguiyaolve", "Xianshoulishangxuduanmi-fang", "Taipinghuiminhejijufang", "Yifangjijie", "Wanshinvke", "Shou Shi Bao Yuan", "Shifanggekuo", "Yilingaicuo", " Xuezhenglun", "Shangkedacheng", " Yixuezhongzhongcanxilu"and other ancient medical books in the treatment of the syndrome of qi stagnation and blood stasis. And Screening 290 oral prescription medicine from the national patent database of existing treatment" the syndrome of qi stagnation and blood stasis ", the take them in TCM inheritance entry auxiliary system (V2.5) "Platform Management"-"Prescription Management" module, established on the syndrome of qi stagnation and blood stasis prescription database analysis system after using the software, data mining, statistics obtained on drug frequency, the data results of drug correlation coefficient to analyze these results, preliminary results and national patent database ancient therapy stagnation core portfolio license for the drug and clinical reference new prescription.Results:commonly used in traditional Chinese medicine syndrome of qi stagnation and Blood Stasis Treatment of ancient medical books are of 27 types, high frequency of use medicine are:Honghua (Carthamus tinctorius L.) 14 times, Danggui (radix angelicae sinensis) 13 times, Taoren (Prunus persica) 12 times, Gancao (Glycyrrhiza glabra L) 11 times, Chishao (Paeonia albiflora Pallas) 11 times, Xiangfu (Cyperus rotundus L.) 1 times, Chuanxiong (Ligusticum chuanxiong Hort.) 6 times, Chaihu (radix bupleuri) 6 times, Mudanpi (Paeonia moutan) 6 times. And the commonly used traditional Chinese medicine syndrome of qi stagnation and Blood Stasis Treatment of national patent database has 76 kinds of medicine, the use of high frequency of use medicine are:Danggui (radix angelicae sinensis) 103 times, Danshen (radix salviae miltiorrhizae) 92 times, Chuanxiong (Ligusticum chuanxiong Hort.) 87 times, Yanhusuo (Rhizoma Corydalis) 77 times, Xiangfu (Cyperus rotundus L.) 73 times, Chishao (Paeonia albiflora Pallas) 66 times, Honghua (Carthamus tinctorius L.) 66 times, Huangqi (radix astragali membranacei) 56 times,Gancao (Glycyrrhiza glabra L.) 54 times, Baishao (Paeonia albiflora Pallas) 49 times, Taoren (Prunus persica) 48 times, Chaihu (radix bupleuri) 46 times, Sanqi (Panax pseudoginseng) 39 times, Niuxi (Achyranthes bidentata BI.) 39 times, Ezhu (rhizoma curcumae zedoariae) 35 times, Fuling (sclerotium poriae cocos) 33 times,31 times,28 times and 28 times three, Radix Aucklandiae, motherwort 28 times. The common use of the combination of drugs of qi stagnation and Blood Stasis Treatment of ancient medical books has several types too.Conclusion:the use of modern methods of data mining, analysis of prescription drug laws by frequency statistics method, the improved mutual information method, the complex system entropy clustering, unsupervised hierarchical clustering methods such as entropy of stagnation of Qi and blood stasis in treatment of ancient medical books and national patents in the database, the feasibility and scientific nature for the clinical treatment of qi stagnation blood stasis syndrome has a certain reference value.