Study On The Relationship Between NDKA, NMDA, PARK7, UFDP And Phlegm - Heat Syndrome And NIHSS In Acute Stage Of Stroke

Objective:To explore the relationship between biomarkers and syndrome of acute ischemic stroke patients.To explore the correlation between biomarkers and neural function defect.To discusses the relationship between biomarkers, syndrome and neural function defect,to provide the reference for the establishment of the biological evaluation system of the Chinese medicine clinical evaluation system.Method:In this study, we adopt patients with acute ischemic stroke and phlegm heat syndrome.The patients were randomly divided into experimental group and control group, experimental group was given the basic treatment of Western medicine and Angong Bezoar Pill Treatment,the control group was given the basic treatment of Western medicine.In the incidence the third day, the seventh day and the fourteenth day, we collecte biomarkers.According to Ischemic Stroke the Syndrome Elements Diagnostic Scale and Ischemic Stroke Syndrome Rating Scale.we diagnose and evaluate the syndrome dynamically. According to United States National Institutes of Health Stroke Scale (NIHSS), we evaluate patients dynamically.We adopt normal people as control and collecte biomarkers one time.Results: ①Characteristics of NDKA, NMDA, PARK7, UFDP in acute ischemia stroke:the content of NDKA, NMDA of acute ischemic stroke patients was higher than that of normal controls (P<0.05), and there was no statistically difference of PARK7 and UFDP levels between and normal controls (P>0.05). In the incidence of the third day, the seventh day and the fourteenth day, NMDA,NDKA,PARK7 and UFDP had no statistically difference (P> 0.05).In the three time points.the content of NDKA firstly decreased and then increased, NMDA, PARK7 and UFDP were decreased gradually.The outcomes suggest NDKA, NMDA may be used as indicators of early diagnosis of cerebral infarction. ②The relationship between NDKA, NMDA, PARK7, UFDP:there was a significant positive correlation between NDKA, NMDA, PARK7, UFDP of the experimental group in the incidence of the third day, the seventh day and the fourteenth day(P<0.05).There was a significant positive correlation between NMDA, PARK7, UFDP of the experimental group in the incidence of the fourteenth day(P<0.05).There was a significant positive correlation between NDKA, NMDA, PAPK7, UFDP of the control group in the incidence of the third day,the seventh day and the fourteenth day(P<0.05).③The correlation of NDKA, NMDA, PARK7, UFDP and phlegm dampness and fire dyndrome:There was a positive correlation between NMDA, PARK7, UFDP and phlegm dampness scores of the experimental group in the incidence of the third day (P< 0.05).There was a negative correlation between PARK7, UFDP and phlegm dampness scores of the control group in the incidence of the seventh day (P<0.05).There was no linear correlation between NDKA, NMDA,PARK7,UFDP and fire scores of the experimental and control group in the incidence of the third day,the sevenyh day, the fourteenth day.The fire scores and phlegm dampness scores decreased gradually of the experimental group and the control group, NMDA, PARK7, UFDP increased gradually, whether there is correlation between such changes need to be further studied.④The correlation of NDKA, NMDA, PARK7, UFDP and NIHSS:There was no linear correlation between NDKA, NMDA, PARK7, UFDP and NIHSS scores of the experimental group(P>0.05).There was no linear correlation between NDKA, NMDA, PARK7, UFDP and NIHSS scores of the control group.The NIHSS scores of the experimental group and the control group decreased gradually, and NMDA, PARK7, UFDP content increased gradually,if there is a correlation between the trends, it needs further study 。Conclusion:NDKA, NMDA may be used as indicators of early diagnosis of cerebral infarction.The relation between NDKA, NMDA, PARK7, UFDP and dyndrome need further studies.The relation between NDKA, NMDA, PARK7, UFDP and neural function defect need further studies.