Efficacy Of Mulberry White Soup In The Treatment Of Acute Exacerbation Of Chronic Obstructive Pulmonary Disease (phlegm - Heat And Lung - Type)

Objective:to observe the effect of medium frequency iontophoresis with white mulberry root bark decoction on phlegm-heat type acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in terms of patients’ clinical effect and safety index.Methods:According to the diagnostic standard,64cases included in this experiment were randomly divided into treatment group and control group,32cases in each group. Routine treatments such as oxygen uptake, anti-infection, bronchodilation, and phlegm reduction were applied to both groups. In addition to routine western medicine treatments, medium frequency iontophoresis with white mulberry root bark decoction were applied to patients from treatment group on their bilateral lung shu acupuncture points for7days. Blood routine examinations, blood gas analyses, pulmonary function, and safety index examinations were conducted before and after the treatment, and indicators of therapeutic effects were recorded and scored. After the experiment, traditional Chinese medicine symptoms, symptom scores and experiment data of patients from both groups were summarized and analyzed to draw research conclusions.Results:There are one case of drop out in treatment group and2cases of drop out in control group. The results indicate that:(1). The overall curative effects of patients from both groups are similar (P>0.05), however, treatment group is superior to control group with regard to clinical control rate and efficiency(P<0.01);(2). There are differences in patients’ symptoms, signs, and aggregate score of symptoms before and after the treatment when comparing within each group (P<0.01or P<0.05); in intergroup comparison, treatment group is superior to control group (P<0.01or P<0.05) in terms of aggregate score of symptoms and symptom scores such as cough, the amount of expectoration, chest distress, breath, coated tongue, and constipation;(3). there are significant differences in the white blood cells number and the cell rate of neutrophil granulocyte before and after the treatment in both groups. In intergroup comparison, treatment group is superior to control group (P<0.05) in terms of the improvement of white blood cells number and the cell rate of neutrophil granulocyte (P <0.05);(4). there are difference in PaCO2and PaO2of patients from both groups before and after the treatment when comparing within each group (P<0.01or P<0.05); in intergroup comparison, treatment group is superior to control group (P<0.05) with regard to the improvement of PaCO2, while there is no different of PaO2between two group after the treatment (P>0.05).Conclusions:the treatment of medium frequency iontophoresis with white mulberry root bark decoction combined with western medicine has distinct advantages in clinical control rate and efficiency, and was able to better improve patients’ clinical symptoms and signs. Treatment group is superior to control group in terms of the effect on white blood cells number and the cell rate of neutrophil granulocyte, it also has an advantage over control group with regard to the improvement of carbon dioxide retention. No obvious adverse reactions were observed during the treatment, which indicates that the treatment can be applied to patients with phlegm-heat type AECOPD.