Effect Of RAS On Hypertension And Its Mechanism

Objective:The purpose of this study is to use the angiotensin converting enzyme inhibitor (ACEI) Lotensin and angiotensin â…¡ receptor antagonist (ARB) Stan on primary hypertension (Essential, Hypertension, EH) treatment, using radioimmunoassay to detect PRA, Angll, ALD and ET before and after treatment, monitoring of24hours ambulatory blood pressure, and compared before and after treatment were observed, Lotensin and Stan the existence of plasma aldosterone (Aldosterone, ALD) and blood pressure changes escape phenomenon, get the influence of RAS on hypertension and its mechanism from.Methods:100patients with primary hypertension patients, randomly divided into Lotensin group (10mg/d) and valsartan group (80mg/d), the two group were50cases. The time of taking medicine for4weeks, simultaneous recording of dynamic blood pressure before and after treatment in patients with hypertension and dynamic electrocardiogram, three time selection of circadian blood pressure fluctuation is the most representative of the corresponding HRV automatic analysis software system for analysis of time domain and frequency domain parameters respectively, and measured two groups before and after the treatment of plasma renin activity (PRA), angiotensin â…¡ (Angâ…¡), aldosterone (ALD).Results:compared with valsartan group and Lotensin group, no significant difference between the two indexes before treatment, and after treatment, PRA, Angll, ALD, SBP, DBP decreased with statistical significance, but no significant difference between the endothelium, ALD valsartan group decreased obviously and have statistical significance; and Lotensin group and valsartan group use of self contrast:Lotensin group after administration of ET, SBP and DBP were significantly decreased, with statistical significance, significant difference before and after PRA Angâ…¡ treatment, no significant difference before and after treatment, ALD no, but there has been an increasing trend before and after medication; valsartan group Angâ…¡, ALD, ET, SBP, DBP decreased statistically significant, difference PRA before and after treatment had No.Conclusion (1) increased ALD plasma levels of Lotensin group after treatment, and valsartan groups were statistically significant (P<0.05), suggesting the presence of aldosterone escape phenomenon.(2)Lotensin and valsartan can lower blood pressure, may be related to the effect of the renin angiotensin system.